Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment

• Published in: Hippocampus Vol. 24; no. 3; pp. 303 - 314
• Main Authors: Reagh, Zachariah M., Roberts, Jared M., Ly, Maria, DiProspero, Natalie, Murray, Elizabeth, Yassa, Michael A.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2014; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aging - physiology; Aging - psychology; Discrimination Learning - physiology; Discrimination, Psychological - physiology; Female; hippocampus; Hippocampus - physiopathology; Humans; interference; Male; Memory Disorders - physiopathology; Memory Disorders - psychology; Memory, Episodic; Mental Recall; Middle Aged; neurocognitive aging; Neuropsychological Tests; pattern separation; Space Perception - physiology; spatial discrimination; Verbal Learning; Young Adult; spatial discrimination; pattern separation; interference; hippocampus; neurocognitive aging

ABSTRACT It is well established that aging is associated with declines in episodic memory. In recent years, an emphasis has emerged on the development of behavioral tasks and the identification of biomarkers that are predictive of cognitive decline in healthy as well as pathological aging. Here, we...