SARS‐CoV‐2 spike protein enhances MAP4K3/GLK‐induced ACE2 stability in COVID‐19

• Published in: EMBO molecular medicine Vol. 14; no. 9; pp. e15904 - n/a
• Main Authors: Chuang, Huai‐Chia, Hsueh, Chia‐Hsin, Hsu, Pu‐Ming, Huang, Rou‐Huei, Tsai, Ching‐Yi, Chung, Nai‐Hsiang, Chow, Yen‐Hung, Tan, Tse‐Hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.09.2022; EMBO Press; John Wiley and Sons Inc; Springer Nature
• Subjects: ACE2; Angiotensin-converting enzyme 2; Cancer; Coronaviruses; COVID-19; EMBO23; EMBO56; Epithelial cells; Exosomes; Gene expression; Genomes; Infections; Kinases; Lysine; MAP4K3/GLK; Pathogenesis; Patients; Protein transport; Proteins; Proteomics; SARS‐CoV‐2; Severe acute respiratory syndrome coronavirus 2; Spike protein; Ubiquitin-protein ligase; Ubiquitination; UBR4; Taiwan; UBR4; ACE2; COVID‐19; SARS‐CoV‐2; MAP4K3/GLK

ACE2 on epithelial cells is the SARS‐CoV‐2 entry receptor. Single‐cell RNA‐sequencing data derived from two COVID‐19 cohorts revealed that MAP4K3/GLK‐positive epithelial cells were increased in patients. SARS‐CoV‐2‐induced GLK overexpression in epithelial cells was correlated with COVID‐19 severity...