An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers

• Published in: Angewandte Chemie International Edition Vol. 54; no. 9; pp. 2784 - 2787
• Main Authors: Schmidt, Sandy, Scherkus, Christian, Muschiol, Jan, Menyes, Ulf, Winkler, Till, Hummel, Werner, Gröger, Harald, Liese, Andreas, Herz, Hans-Georg, Bornscheuer, Uwe T.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 23.02.2015; WILEY‐VCH Verlag
• Subjects: Alcohol dehydrogenase; Alcohol Dehydrogenase - chemistry; Alcohol Dehydrogenase - metabolism; Baeyer-Villiger monooxygenases; Candida antarctica; cascade reactions; Cascades; enzyme catalysis; Mixed Function Oxygenases - chemistry; Mixed Function Oxygenases - metabolism; Molecular Structure; Oligomers; Oxidation; Polyesters - chemistry; Polyesters - metabolism; polymer synthesis; Polymerization; Product inhibition; Synthesis; ε-caprolactone; cascade reactions; enzyme catalysis; polymer synthesis; Baeyer-Villiger monooxygenases; ε-caprolactone

Poly‐ε‐caprolactone (PCL) is chemically produced on an industrial scale in spite of the need for hazardous peracetic acid as an oxidation reagent. Although Baeyer–Villiger monooxygenases (BVMO) in principle enable the enzymatic synthesis of ε‐caprolactone (ε‐CL) directly from cyclohexanone with mole...