Mechanical regulation of T-cell functions

• Published in: Immunological reviews Vol. 256; no. 1; pp. 160 - 176
• Main Authors: Chen, Wei, Zhu, Cheng
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2013
• Subjects: Actin; Animals; catch bonds; Cell Movement; cell surface receptors; conformational change; Humans; Immunological Synapses - physiology; Integrins - chemistry; Integrins - metabolism; Lymphocyte Activation; mechanoregulated molecular interaction; mechanosensing; Protein Conformation; protein mechanochemistry; Receptors, Immunologic - metabolism; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; mechanosensing; cell surface receptors; mechanoregulated molecular interaction; catch bonds; conformational change; protein mechanochemistry

Summary T cells are key players of the mammalian adaptive immune system. They experience different mechanical microenvironments during their life cycle, from the thymus, secondary lymph organs, and peripheral tissues that are free of externally applied force, but display variable substrate rigiditie...