A Phase I, Single-Ascending-Dose Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DS-2969b, a Novel GyrB Inhibitor - Dennie, Justin; Vandell, Alexander G; Inoue, Satoshi; Gajee, Roohi; Pav, Joseph; Zhang, George; Zamora, Cynthia; Masuda, Nobuhisa; Uchiyama, Minoru; Yamada, Makiko; Senaldi, Giorgio (Journal of clinical pharmacology, 2018)
Keywords: Adolescent; Adult; Area Under Curve; Bacteria - drug effects; Dose-Response Relationship, Drug; Female; Gastrointestinal Microbiome - drug effects; Half-Life; Humans; Imidazoles - administration & dosage; Imidazoles - adverse effects; Imidazoles - blood; Imidazoles - pharmacokinetics; Male; Middle Aged; Molecular Structure; Piperidines - administration & dosage; Piperidines - adverse effects; Piperidines - blood; Piperidines - pharmacokinetics; Thiadiazoles - administration & dosage; Thiadiazoles - adverse effects; Thiadiazoles - blood; Thiadiazoles - pharmacokinetics; Topoisomerase II Inhibitors - administration & dosage; Topoisomerase II Inhibitors - adverse effects; Topoisomerase II Inhibitors - blood; Topoisomerase II Inhibitors - pharmacokinetics; Young Adult; DS-2969b; antibiotic; antimicrobial agents; Clostridium difficile infection; Clostridium difficile