Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit

• Published in: Advanced science Vol. 12; no. 1; pp. e2407649 - n/a
• Main Authors: Badar, Waqas, Inamdar, Sheetal R., Fratzl, Peter, Snow, Tim, Terrill, Nicholas J., Knight, Martin M., Gupta, Himadri S.
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.01.2025; John Wiley and Sons Inc; Wiley
• Subjects: 3D diffraction modelling; Animals; Biomechanics; Bone and Bones - metabolism; bone‐cartilage interface; Calcification; Cartilage; Cartilage - metabolism; Cartilage, Articular - diagnostic imaging; Cartilage, Articular - metabolism; Collagen; Collagen - chemistry; Collagen - metabolism; collagen fibrils; Deformation; Hydrogels; nanoscale mechanics; Osteoarthritis; Physiology; Scattering, Small Angle; small‐angle x‐ray scattering; Stress, Mechanical; X-Ray Diffraction - methods; nanoscale mechanics; collagen fibrils; small‐angle x‐ray scattering; bone‐cartilage interface; 3D diffraction modelling

By developing a 3D X‐ray modeling and spatially correlative imaging method for fibrous collagenous tissues, this study provides a comprehensive mapping of nanoscale deformation in the collagen fibril network across the intact bone‐cartilage unit (BCU), whose healthy functioning is critical for joint...