Supernatants from dengue virus type-2 infected macrophages induce permeability changes in endothelial cell monolayers

• Published in: Journal of medical virology Vol. 69; no. 4; pp. 521 - 528
• Main Authors: Carr, Jillian M., Hocking, Helen, Bunting, Karen, Wright, Peter J., Davidson, Andrew, Gamble, Jennifer, Burrell, Christopher J., Li, Peng
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.04.2003; Wiley-Liss
• Subjects: Biological and medical sciences; capillary leakage; Cell Membrane Permeability; Cells, Cultured; dengue haemorrhagic fever; Dengue Virus - physiology; Endothelium, Vascular - cytology; Endothelium, Vascular - physiology; flavivirus; Fundamental and applied biological sciences. Psychology; human umbilical vein endothelial cell; Humans; Macrophages - virology; Microbiology; Monocytes - virology; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Tumor Necrosis Factor-alpha - metabolism; Umbilical Veins; Virology; Endothelial cell; Dengue hemorrhagic fever; Cell permeability; Pathogenesis; Dengue; Dengue virus 2; Flavivirus; Host virus relation; Infection; Virus; Viral disease; Dengue group virus; Arbovirus disease; Flaviviridae; Macrophage

The ability of dengue virus‐infected human monocyte‐derived macrophages to induce permeability changes in primary human umbilical vein endothelial cells was investigated. Supernatants from dengue virus type 2‐infected monocyte‐derived macrophages increased permeability in human umbilical vein endoth...