Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence both HBV infection and hepatocellular carcinoma development

• Published in: Molecular carcinogenesis Vol. 54; no. 11; pp. 1275 - 1282
• Main Authors: Wen, Juan, Liu, Yao, Liu, Jibin, Liu, Li, Song, Ci, Han, Jing, Zhu, Liguo, Wang, Cheng, Chen, Jianguo, Zhai, Xiangjun, Shen, Hongbin, Hu, Zhibin
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2015; Wiley Subscription Services, Inc
• Subjects: Alleles; Carcinoma, Hepatocellular - genetics; Case-Control Studies; Cell Line, Tumor; DNA-Binding Proteins - genetics; eQTLs; Female; Gene loci; Genetic Predisposition to Disease - genetics; Genotype; HCC; Hep G2 Cells; Hepatitis; Hepatitis B virus; Hepatitis B virus - pathogenicity; Hepatitis B, Chronic - genetics; Hepatitis B, Chronic - virology; Humans; Liver cancer; Liver Neoplasms - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Quantitative Trait Loci - genetics; Ribonucleic acid; RNA; RNA, Antisense - genetics; RNA, Long Noncoding - genetics; RNA, Messenger - genetics; susceptibility; ZNRD1; HCC; eQTLs; ZNRD1; susceptibility

Zinc ribbon domain containing 1 (ZNRD1), cloned from human leukocyte antigen (HLA) region, may play integral roles in diverse processes including immune response against HBV infection and hepatocarcinogenesis. ZNRD1‐AS1 (ZNRD1 antisense RNA 1) may be an important regulator of ZNRD1. By bioinformatic...