Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome

• Published in: Pain (Amsterdam) Vol. 154; no. 9; pp. 1528 - 1541
• Main Authors: Ellingson, Benjamin M., Mayer, Emeran, Harris, Robert J., Ashe-McNally, Cody, Naliboff, Bruce D., Labus, Jennifer S., Tillisch, Kirsten
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.09.2013; Lippincott Williams & Wilkins, Inc; Elsevier
• Subjects: Adult; Anisotropy; Biological and medical sciences; Brain - pathology; Brain - physiopathology; Brain Mapping; Chronic Disease; Chronic Pain; Diffusion Tensor Imaging; DTI; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; IBS; Image Processing, Computer-Assisted; Irritable Bowel Syndrome; Irritable Bowel Syndrome - pathology; Male; Medical sciences; Middle Aged; Nerve Net - pathology; Neural Pathways - pathology; Other diseases. Semiology; Reorganization; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Vertebrates: nervous system and sense organs; Young Adult; DTI; IBS; Irritable Bowel Syndrome; Reorganization; Diffusion Tensor Imaging; Chronic Pain; Chronic; Pain; Central nervous system; Irritable bowel syndrome; Digestive diseases; Intestinal disease; Encephalon; Diffusion tensor imaging

The current study involving patients with chronic visceral pain associated with irritable bowel syndrome demonstrates microstructural differences in the brain compared with healthy control subjects, indicative of long-term neural reorganization of chronic pain pathways and regions associated with se...