Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome
The current study involving patients with chronic visceral pain associated with irritable bowel syndrome demonstrates microstructural differences in the brain compared with healthy control subjects, indicative of long-term neural reorganization of chronic pain pathways and regions associated with se...
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| Published in | Pain (Amsterdam) Vol. 154; no. 9; pp. 1528 - 1541 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Philadelphia, PA
Elsevier B.V
01.09.2013
Lippincott Williams & Wilkins, Inc Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The current study involving patients with chronic visceral pain associated with irritable bowel syndrome demonstrates microstructural differences in the brain compared with healthy control subjects, indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration.
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurring abdominal pain associated with alterations in bowel habits. We hypothesized that patients with chronic visceral pain associated with IBS may have microstructural differences in the brain compared with healthy control subjects (HCs), indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration. In the current study we performed population-based voxel-wise diffusion tensor imaging (DTI) comparisons and probabilistic tractography in a large sample of phenotyped patients with IBS (n=33) and in HCs (n=93). Patients had lower fractional anisotropy (FA) in thalamic regions, the basal ganglia (BG) and sensory/motor association/integration regions as well as higher FA in frontal lobe regions and the corpus callosum. In addition, patients had reduced mean diffusivity (MD) within the globus pallidus (GP) and higher MD in the thalamus, internal capsule, and coronal radiata projecting to sensory/motor regions, suggestive of differential changes in axon/dendritic density in these regions. Sex differences in FA and MD were also observed in the patients but not in HCs. Probabilistic tractography in patients confirmed a higher degree of connectivity between the thalamus and prefrontal cortex, as well as between the medial dorsal thalamic nuclei and anterior cingulate cortex, and a lower degree of connectivity between the GP and thalamus. Together, these results support the hypothesis that patients with chronically recurring visceral pain from IBS have long-term microstructural changes within the brain, particularly in regions associated with integration of sensory information and corticothalamic modulation. |
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| AbstractList | Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurring abdominal pain associated with alterations in bowel habits. We hypothesized patients with chronic visceral pain associated with IBS may have microstructural differences in the brain compared with healthy control subjects (HCs), indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration. In the current study we performed population-based voxel-wise DTI comparisons and probabilistic tractography in a large sample of phenotyped patients with IBS (n=33) and HCs (n=93). Patients had lower fractional anisotropy (FA) in thalamic regions, the basal ganglia and sensory/motor association/integration regions as well as higher FA in frontal lobe regions and the corpus callosum. In addition, patients had reduced mean diffusivity (MD), within the globus pallidus, and higher MD in the thalamus, internal capsule, and coronal radiata projecting to sensory/motor regions, suggestive of differential changes in axon/dendritic density in these regions. Sex differences in FA and MD were also observed in the patients but not in HCs. Probabilistic tractography confirmed a higher degree of connectivity in patients between the thalamus and pre-frontal cortex, as well as the medial dorsal thalamic nuclei and anterior cingulate cortex, and a lower degree of connectivity between the globus pallidus and thalamus. Together, these results support the hypothesis that patients with chronically recurring visceral pain from IBS have long-term microstructural changes within the brain, particular in regions associated with integration of sensory information and cortico thalamic modulation. Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurring abdominal pain associated with alterations in bowel habits. We hypothesized that patients with chronic visceral pain associated with IBS may have microstructural differences in the brain compared with healthy control subjects (HCs), indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration. In the current study we performed population-based voxel-wise diffusion tensor imaging (DTI) comparisons and probabilistic tractography in a large sample of phenotyped patients with IBS (n=33) and in HCs (n=93). Patients had lower fractional anisotropy (FA) in thalamic regions, the basal ganglia (BG) and sensory/motor association/integration regions as well as higher FA in frontal lobe regions and the corpus callosum. In addition, patients had reduced mean diffusivity (MD) within the globus pallidus (GP) and higher MD in the thalamus, internal capsule, and coronal radiata projecting to sensory/motor regions, suggestive of differential changes in axon/dendritic density in these regions. Sex differences in FA and MD were also observed in the patients but not in HCs. Probabilistic tractography in patients confirmed a higher degree of connectivity between the thalamus and prefrontal cortex, as well as between the medial dorsal thalamic nuclei and anterior cingulate cortex, and a lower degree of connectivity between the GP and thalamus. Together, these results support the hypothesis that patients with chronically recurring visceral pain from IBS have long-term microstructural changes within the brain, particularly in regions associated with integration of sensory information and corticothalamic modulation. Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurring abdominal pain associated with alterations in bowel habits. We hypothesized that patients with chronic visceral pain associated with IBS may have microstructural differences in the brain compared with healthy control subjects (HCs), indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration. In the current study we performed population-based voxel-wise diffusion tensor imaging (DTI) comparisons and probabilistic tractography in a large sample of phenotyped patients with IBS (n=33) and in HCs (n=93). Patients had lower fractional anisotropy (FA) in thalamic regions, the basal ganglia (BG) and sensory/motor association/integration regions as well as higher FA in frontal lobe regions and the corpus callosum. In addition, patients had reduced mean diffusivity (MD) within the globus pallidus (GP) and higher MD in the thalamus, internal capsule, and coronal radiata projecting to sensory/motor regions, suggestive of differential changes in axon/dendritic density in these regions. Sex differences in FA and MD were also observed in the patients but not in HCs. Probabilistic tractography in patients confirmed a higher degree of connectivity between the thalamus and prefrontal cortex, as well as between the medial dorsal thalamic nuclei and anterior cingulate cortex, and a lower degree of connectivity between the GP and thalamus. Together, these results support the hypothesis that patients with chronically recurring visceral pain from IBS have long-term microstructural changes within the brain, particularly in regions associated with integration of sensory information and corticothalamic modulation.Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurring abdominal pain associated with alterations in bowel habits. We hypothesized that patients with chronic visceral pain associated with IBS may have microstructural differences in the brain compared with healthy control subjects (HCs), indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration. In the current study we performed population-based voxel-wise diffusion tensor imaging (DTI) comparisons and probabilistic tractography in a large sample of phenotyped patients with IBS (n=33) and in HCs (n=93). Patients had lower fractional anisotropy (FA) in thalamic regions, the basal ganglia (BG) and sensory/motor association/integration regions as well as higher FA in frontal lobe regions and the corpus callosum. In addition, patients had reduced mean diffusivity (MD) within the globus pallidus (GP) and higher MD in the thalamus, internal capsule, and coronal radiata projecting to sensory/motor regions, suggestive of differential changes in axon/dendritic density in these regions. Sex differences in FA and MD were also observed in the patients but not in HCs. Probabilistic tractography in patients confirmed a higher degree of connectivity between the thalamus and prefrontal cortex, as well as between the medial dorsal thalamic nuclei and anterior cingulate cortex, and a lower degree of connectivity between the GP and thalamus. Together, these results support the hypothesis that patients with chronically recurring visceral pain from IBS have long-term microstructural changes within the brain, particularly in regions associated with integration of sensory information and corticothalamic modulation. The current study involving patients with chronic visceral pain associated with irritable bowel syndrome demonstrates microstructural differences in the brain compared with healthy control subjects, indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration. Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurring abdominal pain associated with alterations in bowel habits. We hypothesized that patients with chronic visceral pain associated with IBS may have microstructural differences in the brain compared with healthy control subjects (HCs), indicative of long-term neural reorganization of chronic pain pathways and regions associated with sensory integration. In the current study we performed population-based voxel-wise diffusion tensor imaging (DTI) comparisons and probabilistic tractography in a large sample of phenotyped patients with IBS (n=33) and in HCs (n=93). Patients had lower fractional anisotropy (FA) in thalamic regions, the basal ganglia (BG) and sensory/motor association/integration regions as well as higher FA in frontal lobe regions and the corpus callosum. In addition, patients had reduced mean diffusivity (MD) within the globus pallidus (GP) and higher MD in the thalamus, internal capsule, and coronal radiata projecting to sensory/motor regions, suggestive of differential changes in axon/dendritic density in these regions. Sex differences in FA and MD were also observed in the patients but not in HCs. Probabilistic tractography in patients confirmed a higher degree of connectivity between the thalamus and prefrontal cortex, as well as between the medial dorsal thalamic nuclei and anterior cingulate cortex, and a lower degree of connectivity between the GP and thalamus. Together, these results support the hypothesis that patients with chronically recurring visceral pain from IBS have long-term microstructural changes within the brain, particularly in regions associated with integration of sensory information and corticothalamic modulation. |
| Author | Labus, Jennifer S. Naliboff, Bruce D. Ellingson, Benjamin M. Mayer, Emeran Harris, Robert J. Ashe-McNally, Cody Tillisch, Kirsten |
| AuthorAffiliation | Department of Radiological Science, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Biomedical Physics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Bioengineering, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Digestive Diseases and Gastroenterology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA |
| AuthorAffiliation_xml | – name: Department of Radiological Science, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Biomedical Physics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Bioengineering, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Digestive Diseases and Gastroenterology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA – name: 3 Department of Bioengineering, David Geffen School of Medicine, University of California-Los Angeles – name: 4 Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles – name: 1 Department of Radiological Science, David Geffen School of Medicine, University of California-Los Angeles – name: 6 Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California-Los Angeles – name: 5 Department of Digestive Diseases and Gastroenterology, David Geffen School of Medicine, University of California-Los Angeles – name: 2 Department of Biomedical Physics, David Geffen School of Medicine, University of California-Los Angeles |
| Author_xml | – sequence: 1 givenname: Benjamin M. surname: Ellingson fullname: Ellingson, Benjamin M. email: bellingson@mednet.ucla.edu organization: Department of Radiological Science, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA – sequence: 2 givenname: Emeran surname: Mayer fullname: Mayer, Emeran organization: Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA – sequence: 3 givenname: Robert J. surname: Harris fullname: Harris, Robert J. organization: Department of Radiological Science, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA – sequence: 4 givenname: Cody surname: Ashe-McNally fullname: Ashe-McNally, Cody organization: Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA – sequence: 5 givenname: Bruce D. surname: Naliboff fullname: Naliboff, Bruce D. organization: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA – sequence: 6 givenname: Jennifer S. surname: Labus fullname: Labus, Jennifer S. organization: Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA – sequence: 7 givenname: Kirsten surname: Tillisch fullname: Tillisch, Kirsten organization: Center for the Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA |
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| ContentType | Journal Article |
| Copyright | 2013 International Association for the Study of Pain Lippincott Williams & Wilkins, Inc. 2014 INIST-CNRS Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. 2013 |
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| Issue | 9 |
| Keywords | DTI IBS Irritable Bowel Syndrome Reorganization Diffusion Tensor Imaging Chronic Pain Chronic Pain Central nervous system Irritable bowel syndrome Digestive diseases Intestinal disease Encephalon Diffusion tensor imaging |
| Language | English |
| License | CC BY 4.0 Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. |
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| PublicationPlace | Philadelphia, PA |
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| PublicationTitle | Pain (Amsterdam) |
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| PublicationYear | 2013 |
| Publisher | Elsevier B.V Lippincott Williams & Wilkins, Inc Elsevier |
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Sep;154(9):1489-90 |
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| Snippet | The current study involving patients with chronic visceral pain associated with irritable bowel syndrome demonstrates microstructural differences in the brain... Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurring abdominal pain associated with alterations in bowel habits. We... |
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| SubjectTerms | Adult Anisotropy Biological and medical sciences Brain - pathology Brain - physiopathology Brain Mapping Chronic Disease Chronic Pain Diffusion Tensor Imaging DTI Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Humans IBS Image Processing, Computer-Assisted Irritable Bowel Syndrome Irritable Bowel Syndrome - pathology Male Medical sciences Middle Aged Nerve Net - pathology Neural Pathways - pathology Other diseases. Semiology Reorganization Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Vertebrates: nervous system and sense organs Young Adult |
| Title | Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome |
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