Human Umbilical Cord Blood Progenitors: The Potential of These Hematopoietic Cells to Become Neural

• Published in: Stem cells (Dayton, Ohio) Vol. 23; no. 10; pp. 1560 - 1570
• Main Authors: Chen, Ning, Hudson, Jennifer E., Walczak, Piotr, Misiuta, Iwona, Garbuzova‐Davis, Svitlana, Jiang, Lixian, Sanchez‐Ramos, Juan, Sanberg, Paul R., Zigova, Tanja, Willing, Alison E.
• Format: Journal Article
• Language: English
• Published: Bristol John Wiley & Sons, Ltd 01.11.2005
• Subjects: Antigens, CD - metabolism; Cell Adhesion Molecules, Neuronal - metabolism; Cell Culture Techniques; Cell Differentiation - physiology; Cell Survival; Cells, Cultured; Embryo Research; Fetal Blood - cytology; Fetal Proteins - metabolism; Hematopoietic and neural antigens; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - physiology; Human; Humans; Leukocytes, Mononuclear - cytology; Multipotential differentiation; Neural Cell Adhesion Molecules - metabolism; Neurons - cytology; Neuropoiesis; Receptors, Chemokine - metabolism; Stem/progenitor cell; Umbilical cord blood

The mononuclear fraction from human umbilical cord blood (HUCB) contains a significant number of stem/progenitor cells that in theory could be come any cell in the body, including neurons. Taking into consideration that transdifferentiation would be a very rare event and also knowing that overlappin...