Unraveling the role of gut microbiota by fecal microbiota transplantation in rat model of kidney stone disease

• Published in: Scientific reports Vol. 14; no. 1; pp. 21924 - 12
• Main Authors: Hunthai, Sittiphong, Usawachintachit, Manint, Taweevisit, Mana, Srisa-Art, Monpichar, Anegkamol, Weerapat, Tosukhowong, Piyaratana, Rattanachaisit, Pakkapon, Chuaypen, Natthaya, Dissayabutra, Thasinas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.09.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326; 631/45; 692/4025; 692/53; Adult; Animal models; Animals; Antibiotics; Calcium; Calcium (urinary); Calcium oxalate; Calculi; Digestive system; Disease Models, Animal; Dysbacteriosis; Dysbiosis - microbiology; Excretion; Fecal Microbiota Transplantation; Fecal microflora; Feces; Feces - microbiology; Female; Gastrointestinal Microbiome; Gastrointestinal tract; Gut leakage; Gut microbiota; Humanities and Social Sciences; Humans; Hyperoxaluria; Intestinal microflora; Kidney Calculi - metabolism; Kidney Calculi - microbiology; Kidney Calculi - therapy; Kidneys; Lithiasis; Male; Metabolites; Microbiomes; Microbiota; Middle Aged; multidisciplinary; Nephrolithiasis; NF-κB protein; Oxalate; Oxalic acid; Rats; Rats, Wistar; Renal function; Science; Science (multidisciplinary); Supersaturation; Transplantation; Urinary tract diseases; Urolithiasis; Zonula occludens-1 protein; Gut microbiota; Gut leakage; Urolithiasis; Oxalate; Fecal microbiota transplantation

Emerging research on the microbiome highlights the significant role of gut health in the development of kidney stones, indicating that an imbalance in gut bacteria or dysbiosis can influence the formation of stones by altering oxalate metabolism and urinary metabolite profiles. In particular, the ov...