Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality

• Published in: Nature communications Vol. 15; no. 1; pp. 7483 - 15
• Main Authors: Wang, Rongling, Gomez Salazar, Mario, Pruñonosa Cervera, Iris, Coutts, Amanda, French, Karen, Pinto, Marlene Magalhaes, Gohlke, Sabrina, García-Martín, Ruben, Blüher, Matthias, Schofield, Christopher J., Kourtzelis, Ioannis, Stimson, Roland H., Bénézech, Cécile, Christian, Mark, Schulz, Tim J., Gudmundsson, Elias F., Jennings, Lori L., Gudnason, Vilmundur G., Chavakis, Triantafyllos, Morton, Nicholas M., Emilsson, Valur, Michailidou, Zoi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/106; 13/31; 13/51; 38; 38/39; 631/154/53; 631/443/319; 692/308/1426; 82/80; Adipocytes; Adipocytes - metabolism; Adipocytes, Brown - metabolism; Adipose tissue; Adipose tissue (brown); Adipose Tissue, Brown - metabolism; Adult; Animals; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biomarkers; Body fat; Burning; Dormancy; Energy expenditure; Energy Metabolism; Female; Humanities and Social Sciences; Humans; Hypoxia; Hypoxia-Inducible Factor-Proline Dioxygenases - genetics; Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism; Hypoxia-inducible factors; Living conditions; Male; Metabolic disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; multidisciplinary; Oxygen; Oxygen - metabolism; Prolyl hydroxylase; Promoter Regions, Genetic; Proteomics; Science; Science (multidisciplinary); Strategy; Thermogenesis - genetics; Uncoupling Protein 1 - genetics; Uncoupling Protein 1 - metabolism

Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD...