Biphasic kinetics of bacterial killing by quinolones

• Published in: Journal of antimicrobial chemotherapy Vol. 27; no. 3; p. 319
• Main Authors: Carret, G, Flandrois, J P, Lobry, J R
• Format: Journal Article
• Language: English
• Published: England 01.03.1991
• Subjects: Colony Count, Microbial; Escherichia coli - drug effects; Escherichia coli - growth & development; Humans; Infant, Newborn; Models, Theoretical; Nalidixic Acid - pharmacology; Ofloxacin - pharmacology; Pefloxacin - pharmacology

The early phases of the bactericidal dynamics of three quinolones against two Escherichia coli strains were studied. Four concentrations of nalidixic acid, pefloxacin and ofloxacin were tested against each strain. In each case biphasic killing of bacteria was observed after a lag phase, and a biexpo...