Revealing the immune cell subtype reconstitution profile in patients from the CLARITY study using deconvolution algorithms after cladribine tablets treatment

• Published in: Scientific reports Vol. 13; no. 1; p. 8067
• Main Authors: Kalatskaya, Irina, Giovannoni, Gavin, Leist, Thomas, Cerra, Joseph, Boschert, Ursula, Rolfe, P. Alexander
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.05.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/250; Algorithms; Autoimmune diseases; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes; Cladribine; Cladribine - pharmacology; Cladribine - therapeutic use; Clinical trials; Flow cytometry; Gene expression; Homeostasis; Humanities and Social Sciences; Humans; Immunological memory; Immunosuppressive agents; Immunosuppressive Agents - pharmacology; Immunosuppressive Agents - therapeutic use; Inflammation; Lymphocytes B; Lymphocytes T; Macrophages; Memory cells; Mode of action; multidisciplinary; Multiple sclerosis; Multiple Sclerosis - drug therapy; Multiple Sclerosis, Relapsing-Remitting - drug therapy; Patients; Science; Science (multidisciplinary); Tablets; Tablets - therapeutic use

Immune Cell Deconvolution methods utilizing gene expression profiling to quantify immune cells in tissues and blood are an appealing alternative to flow cytometry. Our objective was to investigate the applicability of deconvolution approaches in clinical trial settings to better investigate the mode...