Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau

• Published in: Neurobiology of aging Vol. 80; pp. 11 - 20
• Main Authors: Jacobs, Kelly R., Lim, Chai K., Blennow, Kaj, Zetterberg, Henrik, Chatterjee, Pratishtha, Martins, Ralph N., Brew, Bruce J., Guillemin, Gilles J., Lovejoy, David B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019
• Subjects: 3-dioxygenase; 3-hydroxyanthranilic acid; 3-hydroxykynurenine; Aged; Aged, 80 and over; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid-beta; Amyloid-β; astrocytes; brain; Cerebrospinal fluid; Disease; Disease biomarkers; Female; Geriatrics & Gerontology; human microglia; Humans; hydrogen-peroxide; indoleamine; Kynurenine - blood; Kynurenine - cerebrospinal fluid; Kynurenine pathway; Male; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; quinolinate levels; Signal Transduction; Tau protein; tau Proteins - cerebrospinal fluid; tryptophan; Disease biomarkers; Amyloid-β; Cerebrospinal fluid; Tau protein; Alzheimer's disease; Kynurenine pathway

Chronic kynurenine pathway (KP) activation is implicated in Alzheimer's disease (AD) pathophysiology and results in quinolinic acid–induced excitotoxic stimulation of the N-methyl-D-aspartate receptor. However, most studies focus on plasma and it is unclear if peripheral concentrations reflect...