Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

• Published in: Journal of ethnopharmacology Vol. 156; no. NA; pp. 210 - 215
• Main Authors: Li, Min, Shi, Aixin, Pang, Hongxian, Xue, Wei, Li, Yang, Cao, Guoying, Yan, Bei, Dong, Fan, Li, Kexin, Xiao, Wei, He, Guorong, Du, Guanhua, Hu, Xin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.10.2014
• Subjects: Adult; adults; Area Under Curve; Baicalein; Baicalin; blood; chlorine; clinical trials; cough; Double-Blind Method; drugs; dysentery; feces; Female; fever; Flavanones - administration & dosage; Flavanones - chemistry; Flavanones - pharmacokinetics; Flavonoids - chemistry; fluorine; Half-Life; Healthy Volunteers; hematology; Humans; hypertension; inflammation; kidneys; liquid chromatography; liver; Male; metabolites; oral administration; Oriental traditional medicine; Parkinson׳s Disease; Pharmacokinetics; Safety; Scutellaria baicalensis; Scutellaria baicalensis - chemistry; Tablets - administration & dosage; Tablets - pharmacokinetics; tandem mass spectrometry; Tolerability; toxicity; urinalysis; urine; Young Adult; Parkinson׳s Disease; Baicalin (PubChem CID:64982); Baicalein; Tolerability; Safety; Baicalein (PubChem CID: 5281605); Pharmacokinetics; Baicalin

The root of Scutellaria baicalensis Georgi has been used extensively in traditional Chinese medicine for the treatment of inflammation, fever, cough, dysentery, and hypertension. Baicalein is a flavonoid isolated from the root of Scutellaria baicalensis Georgi and is a novel neuroprotective agent un...