Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

• Published in: Molecular and cellular endocrinology Vol. 552; p. 111676
• Main Authors: Slate-Romano, John J., Yano, Naohiro, Zhao, Ting C.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.07.2022
• Subjects: cell viability; Cytokines; Diabetes Mellitus, Type 2 - metabolism; endocrinology; energy expenditure; exercise; Fibronectins - metabolism; glucose tolerance; homeostasis; Humans; inflammasomes; Inflammation; insulin resistance; lipids; macrophages; Metabolic Syndrome; muscles; osteoblasts; permeability; Signal Transduction; white adipose tissue

Irisin is an exercise induced myokine first shown to induce the browning of white adipose tissue (WAT) which increases energy expenditure, improves glucose tolerance, and reduces insulin resistance. Among irisin's involvement in lipid homeostasis, osteoblast proliferation, and muscle growth, it...