The NF-κB signalling pathway in osteoarthritis

• Published in: The international journal of biochemistry & cell biology Vol. 45; no. 11; pp. 2580 - 2584
• Main Authors: Rigoglou, Stella, Papavassiliou, Athanasios G.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.11.2013
• Subjects: Animals; Arrays; Biocompatibility; Biomedical materials; Cartilage destruction; chemokines; Chondrocytes; Cytokines; Degradation; evolution; extracellular matrix; Gene expression; genes; Humans; Models, Biological; NF-kappa B - metabolism; NF-κB; Osteoarthritis; Osteoarthritis - metabolism; Osteoarthritis - pathology; Osteoarthritis - therapy; pathogenesis; Pathways; proteins; Signal Transduction; Signalling; transcription factor NF-kappa B; NF-κB; Signal transduction; Cartilage destruction; Osteoarthritis; Chondrocytes

•Osteoarthritis (OA) is a degenerative disease affecting all compartments of the joint.•NF-κB signalling pathway is a major catabolic pathway in OA joints.•NF-κB triggers the expression of various genes which are implicated in cartilage destruction, synovial membrane inflammation and increased subch...