Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters - Yuan, Shuofeng; Wang, Runming; Chan, Jasper Fuk-Woo; Zhang, Anna Jinxia; Cheng, Tianfan; Chik, Kenn Ka-Heng; Ye, Zi-Wei; Wang, Suyu; Lee, Andrew Chak-Yiu; Jin, Lijian; Li, Hongyan; Jin, Dong-Yan; et al. (Nature microbiology, 2020)
Keywords: 631/154; 631/326/22/1295; 631/326/596/4130; Adenosine triphosphatase; Animals; Antimicrobial agents; Antiviral agents; Antiviral Agents - pharmacology; Betacoronavirus - drug effects; Betacoronavirus - physiology; Biomedical and Life Sciences; Bismuth - pharmacology; Chemokines - metabolism; Chlorocebus aethiops; Citric acid; Coronavirus Infections - drug therapy; Coronavirus Infections - virology; Coronaviruses; COVID-19; Cytokines - metabolism; Cytotoxicity; Disease Models, Animal; DNA helicase; HEK293 Cells; Helicobacter pylori; Humans; Infections; Infectious Diseases; Infectivity; Life Sciences; Lung - pathology; Lung - virology; Medical Microbiology; Mesocricetus; Microbiology; Pandemics; Parasitology; Pneumonia; Pneumonia, Viral - drug therapy; Pneumonia, Viral - virology; Ranitidine; Ranitidine - analogs & derivatives; Ranitidine - pharmacology; Ranitidine bismuth citrate; Replication; RNA Helicases - metabolism; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Unwinding; Vero Cells; Viral Load; Virology; Virus Replication - drug effects