Single-cell transcriptome analysis of epithelial, immune, and stromal signatures and interactions in human ovarian cancer

• Published in: Communications biology Vol. 7; no. 1; pp. 131 - 15
• Main Authors: Chai, Chaochao, Liang, Langchao, Mikkelsen, Nanna S., Wang, Wei, Zhao, Wandong, Sun, Chengcheng, Bak, Rasmus O., Li, Hanbo, Lin, Lin, Wang, Fei, Luo, Yonglun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/109; 42; 42/41; 45; 45/44; 631/114/2164; 631/67/1517/1709; Biomedical and Life Sciences; CD8 antigen; Cell proliferation; CRISPR; Epithelial cells; Extracellular matrix; Life Sciences; Lymphocytes T; Molecular modelling; Ovarian cancer; Transcriptomes; Tumor microenvironment; Tumors

A comprehensive investigation of ovarian cancer (OC) progression at the single-cell level is crucial for enhancing our understanding of the disease, as well as for the development of better diagnoses and treatments. Here, over half a million single-cell transcriptome data were collected from 84 OC p...