3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo microcomputed tomography (μCT)
Abstract In the recent decade, in vivo μCT scanners have become available to monitor temporal changes in rodent bone in response to diseases and treatments. We investigated short-term and long-term precision of in vivo μCT measurements of trabecular bone density, microstructure and stiffness of rat...
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Published in | Bone (New York, N.Y.) Vol. 56; no. 1; pp. 83 - 90 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
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Amsterdam
Elsevier Inc
01.09.2013
Elsevier |
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Abstract | Abstract In the recent decade, in vivo μCT scanners have become available to monitor temporal changes in rodent bone in response to diseases and treatments. We investigated short-term and long-term precision of in vivo μCT measurements of trabecular bone density, microstructure and stiffness of rat tibiae and tested whether they can be improved by 3D image registration. Rats in the short-term precision group underwent baseline and follow-up scans within the same day (n = 15) and those in the long-term precision group were scanned at day 0 and day 14 (n = 16) at 10.5 μm voxel size. A 3D image-registration scheme was applied to register the trabecular bone compartments of baseline and follow-up scans. Prior to image registration, short-term precision ranged between 0.85% and 2.65% in bone volume fraction (BV/TV), trabecular number, thickness, and spacing (Tb.N*, Tb.Th*, Tb.Sp*), trabecular bone mineral density and tissue mineral density (Tb.BMD, and Tb.TMD), and was particularly high in structure model index (SMI), connectivity density (Conn.D), and stiffness (4.29%–8.83%). Image registration tended to improve the short-term precision, but the only statistically significant improvement was in Tb.N*, Tb.TMD, and stiffness. On the other hand, unregistered comparisons between day-0 and day-14 scans suggested significant increases in BV/TV, Tb.N*, Tb.Th*, Conn.D, and Tb.BMD and decrease in Tb.Sp* and SMI. However, the percent change in each parameter from registered comparisons was significantly different from unregistered comparisons. Registered results suggested a significant increase in BV/TV, Tb.BMD, and stiffness over 14 days, primarily caused by increased Tb.Th* and Tb.TMD. Due to the continuous growth of rodents, the direct comparisons between the unregistered baseline and follow-up scans were driven by changes due to global bone modeling instead of local remodeling. Our results suggested that 3D image registration is critical for detecting changes due to bone remodeling activities in rodent trabecular bone by in vivo μCT imaging. |
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AbstractList | In the recent decade, in vivo μCT scanners have become available to monitor temporal changes in rodent bone in response to diseases and treatments. We investigated short-term and long-term precision of in vivo μCT measurements of trabecular bone density, microstructure and stiffness of rat tibiae and tested whether they can be improved by 3D image registration. Rats in the short-term precision group underwent baseline and follow-up scans within the same day (n = 15) and those in the long-term precision group were scanned at day 0 and day 14 (n = 16) at 10.5 μm voxel size. A 3D image-registration scheme was applied to register the trabecular bone compartments of baseline and follow-up scans. Prior to image registration, short-term precision ranged between 0.85% and 2.65% in bone volume fraction (BV/TV), trabecular number, thickness, and spacing (Tb.N*, Tb.Th*, Tb.Sp*), trabecular bone mineral density and tissue mineral density (Tb.BMD, and Tb.TMD), and was particularly high in structure model index (SMI), connectivity density (Conn.D), and stiffness (4.29%-8.83%). Image registration tended to improve the short-term precision, but the only statistically significant improvement was in Tb.N*, Tb.TMD, and stiffness. On the other hand, unregistered comparisons between day-0 and day-14 scans suggested significant increases in BV/TV, Tb.N*, Tb.Th*, Conn.D, and Tb.BMD and decrease in Tb.Sp* and SMI. However, the percent change in each parameter from registered comparisons was significantly different from unregistered comparisons. Registered results suggested a significant increase in BV/TV, Tb.BMD, and stiffness over 14 days, primarily caused by increased Tb.Th* and Tb.TMD. Due to the continuous growth of rodents, the direct comparisons between the unregistered baseline and follow-up scans were driven by changes due to global bone modeling instead of local remodeling. Our results suggested that 3D image registration is critical for detecting changes due to bone remodeling activities in rodent trabecular bone by in vivo μCT imaging. In the recent decade, in vivo μCT scanners have become available to monitor temporal changes in rodent bone in response to diseases and treatments. We investigated short-term and long-term precision of in vivo μCT measurements of trabecular bone density, microstructure and stiffness of rat tibiae and tested whether they can be improved by 3D image registration. Rats in the short-term precision group underwent baseline and follow-up scans within the same day (n=15) and those in the long-term precision group were scanned at day 0 and day 14 (n=16) at 10.5μm voxel size. A 3D image-registration scheme was applied to register the trabecular bone compartments of baseline and follow-up scans. Prior to image registration, short-term precision ranged between 0.85% and 2.65% in bone volume fraction (BV/TV), trabecular number, thickness, and spacing (Tb.N*, Tb.Th*, Tb.Sp*), trabecular bone mineral density and tissue mineral density (Tb.BMD, and Tb.TMD), and was particularly high in structure model index (SMI), connectivity density (Conn.D), and stiffness (4.29%–8.83%). Image registration tended to improve the short-term precision, but the only statistically significant improvement was in Tb.N*, Tb.TMD, and stiffness. On the other hand, unregistered comparisons between day-0 and day-14 scans suggested significant increases in BV/TV, Tb.N*, Tb.Th*, Conn.D, and Tb.BMD and decrease in Tb.Sp* and SMI. However, the percent change in each parameter from registered comparisons was significantly different from unregistered comparisons. Registered results suggested a significant increase in BV/TV, Tb.BMD, and stiffness over 14days, primarily caused by increased Tb.Th* and Tb.TMD. Due to the continuous growth of rodents, the direct comparisons between the unregistered baseline and follow-up scans were driven by changes due to global bone modeling instead of local remodeling. Our results suggested that 3D image registration is critical for detecting changes due to bone remodeling activities in rodent trabecular bone by in vivo μCT imaging. •3D image registration of in vivo μCT images improves short-term precision in trabecular number, tissue mineral density, and stiffness.•Unregistered longitudinal comparisons of in vivo μCT images overestimated increases in bone volume fraction, bone mineral density, and stiffness.•3D registration of in vivo μCT scans 14days apart significantly improved the precision in morphology and density measurements. Abstract In the recent decade, in vivo μCT scanners have become available to monitor temporal changes in rodent bone in response to diseases and treatments. We investigated short-term and long-term precision of in vivo μCT measurements of trabecular bone density, microstructure and stiffness of rat tibiae and tested whether they can be improved by 3D image registration. Rats in the short-term precision group underwent baseline and follow-up scans within the same day (n = 15) and those in the long-term precision group were scanned at day 0 and day 14 (n = 16) at 10.5 μm voxel size. A 3D image-registration scheme was applied to register the trabecular bone compartments of baseline and follow-up scans. Prior to image registration, short-term precision ranged between 0.85% and 2.65% in bone volume fraction (BV/TV), trabecular number, thickness, and spacing (Tb.N*, Tb.Th*, Tb.Sp*), trabecular bone mineral density and tissue mineral density (Tb.BMD, and Tb.TMD), and was particularly high in structure model index (SMI), connectivity density (Conn.D), and stiffness (4.29%–8.83%). Image registration tended to improve the short-term precision, but the only statistically significant improvement was in Tb.N*, Tb.TMD, and stiffness. On the other hand, unregistered comparisons between day-0 and day-14 scans suggested significant increases in BV/TV, Tb.N*, Tb.Th*, Conn.D, and Tb.BMD and decrease in Tb.Sp* and SMI. However, the percent change in each parameter from registered comparisons was significantly different from unregistered comparisons. Registered results suggested a significant increase in BV/TV, Tb.BMD, and stiffness over 14 days, primarily caused by increased Tb.Th* and Tb.TMD. Due to the continuous growth of rodents, the direct comparisons between the unregistered baseline and follow-up scans were driven by changes due to global bone modeling instead of local remodeling. Our results suggested that 3D image registration is critical for detecting changes due to bone remodeling activities in rodent trabecular bone by in vivo μCT imaging. |
Author | Luo, Shiming Altman, Allison R Liu, X. Sherry Chandra, Abhishek Lan, Shenghui Qin, Ling Huh, Beom Kang |
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Cites_doi | 10.1016/j.bone.2003.08.012 10.1016/j.bone.2009.12.015 10.3233/THC-1998-65-613 10.1016/j.bone.2010.10.007 10.1016/0021-9290(94)90019-1 10.1359/jbmr.080808 10.1016/j.bone.2008.01.017 10.1002/jbmr.141 10.1016/j.bone.2011.08.035 10.1109/42.774168 10.1007/s10439-006-9168-7 10.1109/42.845176 10.1002/jor.20913 10.1016/j.imavis.2006.08.002 10.1007/s00223-007-9084-3 10.1023/A:1007958904918 10.1146/annurev.bioeng.3.1.307 10.1016/j.bone.2011.05.013 10.1097/00004728-199707000-00007 10.1002/jor.20063 10.1118/1.3096605 10.1002/jbmr.92 10.1002/jbmr.152 10.1007/s00198-009-1047-2 10.1016/j.bone.2009.09.023 10.1016/j.bone.2004.09.007 10.1016/j.bone.2006.04.017 10.1002/jor.20439 |
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Keywords | 3D image registration Trabecular bone microstructure Animal models/rodent Finite element analysis In vivo μCT Animal model Radiodiagnosis Rat Image processing Rodentia In vivo Vertebrata Mammalia Animal Morphology Tomography Bone mineral density Tridimensional image Stiffness Spongious bone Microstructure Finite element |
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References | Verdelis, Lukashova, Atti, Mayer-Kuckuk, Peterson, Tetradis (bb0080) 2011; 49 Campbell, Buie, Boyd (bb0035) 2008 Bonnet, Laroche, Vico, Dolleans, Courteix, Benhamou (bb0085) 2009; 36 Schulte, Lambers, Kuhn, Muller (bb0055) 2011; 48 Gao, Gu, Lin (bb0150) 2008; 26 Brouwers, Lambers, van Rietbergen, Ito, Huiskes (bb0020) 2009; 27 Collignon, Maes, Delaere, Vandermeulen, Suetens, Marchal (bb0100) 1995 Buie, Moore, Boyd (bb0040) 2008; 23 Bouxsein, Boyd, Christiansen, Guldberg, Jepsen, Muller (bb0005) 2010; 25 Waarsing, Day, Verhaar, Ederveen, Weinans (bb0045) 2006; 24 lbanez, Schroeder, Ng, Cates (bb0105) 2005 Boyd, Davison, Muller, Gasser (bb0030) 2006; 39 van Rietbergen, Majumdar, Pistoia, Newitt, Kothari, Laib (bb0060) 1998; 6 Liu, Zhang, Sekhon, Adams, McMahon, Bilezikian (bb0110) 2010; 25 Lambers, Schulte, Kuhn, Webster, Muller (bb0050) 2011; 49 Vilayphiou, Boutroy, Sornay-Rendu, Van Rietbergen, Munoz, Delmas (bb0140) 2010; 46 Melton, Christen, Riggs, Achenbach, Muller, van Lenthe (bb0135) 2010; 21 Nishiyama, Campbell, Klinck, Boyd (bb0075) 2010; 46 Viola, Wells (bb0095) 1997; 24 Brouwers, Lambers, Gasser, van Rietbergen, Huiskes (bb0015) 2008; 82 Hollister, Brennan, Kikuchi (bb0120) 1994; 27 Guo, Goldstein (bb0115) 1997; 12 West, Fitzpatrick, Wang, Dawant, Maurer, Kessler (bb0145) 1997; 21 Ritter, Owens, Cooper, Eikelboom, van Saarloos (bb0155) 1999; 18 Boyd, Moser, Kuhn, Klinck, Krauze, Muller (bb0070) 2006; 34 Stein, Liu, Nickolas, Cohen, Thomas, McMahon (bb0130) 2010; 25 Waarsing, Day, van der Linden, Ederveen, Spanjers, De Clerck (bb0010) 2004; 34 Macneil, Boyd (bb0125) 2008; 42 Keaveny, Morgan, Niebur, Yeh (bb0065) 2001; 3 Kim, Christopherson, Dong, Fyhrie, Yeni (bb0090) 2004; 35 Brouwers, van Rietbergen, Huiskes (bb0025) 2007; 25 Carrillo, Duerk, Lewin, Wilson (bb0160) 2000; 19 10100943 - Technol Health Care. 1998 Dec;6(5-6):413-20 10875702 - IEEE Trans Med Imaging. 2000 Mar;19(3):175-85 8188724 - J Biomech. 1994 Apr;27(4):433-44 19437511 - J Orthop Res. 2009 Nov;27(11):1521-7 17568420 - J Orthop Res. 2007 Oct;25(10):1325-32 19472637 - Med Phys. 2009 Apr;36(4):1286-97 20533309 - J Bone Miner Res. 2010 Jul;25(7):1468-86 14751574 - Bone. 2004 Jan;34(1):163-9 16757220 - Bone. 2006 Oct;39(4):854-62 18373058 - Osteoporos Int. 2008 Oct;19(10):1409-19 21621659 - Bone. 2011 Sep;49(3):580-7 18684086 - J Bone Miner Res. 2008 Dec;23(12):2048-59 11447066 - Annu Rev Biomed Eng. 2001;3:307-33 19775199 - J Bone Miner Res. 2010 Apr;25(4):746-56 16583450 - J Orthop Res. 2006 May;24(5):926-35 21964411 - Bone. 2011 Dec;49(6):1340-50 10416802 - IEEE Trans Med Imaging. 1999 May;18(5):404-18 19714390 - Osteoporos Int. 2010 Jul;21(7):1161-9 9216759 - J Comput Assist Tomogr. 1997 Jul-Aug;21(4):554-66 18286219 - Calcif Tissue Int. 2008 Mar;82(3):202-11 20950723 - Bone. 2011 Mar 1;48(3):433-42 16957987 - Ann Biomed Eng. 2006 Oct;34(10):1587-99 19796719 - Bone. 2010 Jan;46(1):155-61 20564238 - J Bone Miner Res. 2010 Dec;25(12):2572-81 18358799 - Bone. 2008 Jun;42(6):1203-13 15589219 - Bone. 2004 Dec;35(6):1375-82 20044044 - Bone. 2010 Apr;46(4):1030-7 Campbell (10.1016/j.bone.2013.05.014_bb0035) 2008 Boyd (10.1016/j.bone.2013.05.014_bb0030) 2006; 39 Brouwers (10.1016/j.bone.2013.05.014_bb0020) 2009; 27 Brouwers (10.1016/j.bone.2013.05.014_bb0025) 2007; 25 Carrillo (10.1016/j.bone.2013.05.014_bb0160) 2000; 19 Brouwers (10.1016/j.bone.2013.05.014_bb0015) 2008; 82 Buie (10.1016/j.bone.2013.05.014_bb0040) 2008; 23 Hollister (10.1016/j.bone.2013.05.014_bb0120) 1994; 27 Keaveny (10.1016/j.bone.2013.05.014_bb0065) 2001; 3 van Rietbergen (10.1016/j.bone.2013.05.014_bb0060) 1998; 6 Viola (10.1016/j.bone.2013.05.014_bb0095) 1997; 24 Ritter (10.1016/j.bone.2013.05.014_bb0155) 1999; 18 Lambers (10.1016/j.bone.2013.05.014_bb0050) 2011; 49 Melton (10.1016/j.bone.2013.05.014_bb0135) 2010; 21 Waarsing (10.1016/j.bone.2013.05.014_bb0045) 2006; 24 Collignon (10.1016/j.bone.2013.05.014_bb0100) 1995 Vilayphiou (10.1016/j.bone.2013.05.014_bb0140) 2010; 46 Boyd (10.1016/j.bone.2013.05.014_bb0070) 2006; 34 Schulte (10.1016/j.bone.2013.05.014_bb0055) 2011; 48 Liu (10.1016/j.bone.2013.05.014_bb0110) 2010; 25 lbanez (10.1016/j.bone.2013.05.014_bb0105) 2005 Macneil (10.1016/j.bone.2013.05.014_bb0125) 2008; 42 Kim (10.1016/j.bone.2013.05.014_bb0090) 2004; 35 West (10.1016/j.bone.2013.05.014_bb0145) 1997; 21 Verdelis (10.1016/j.bone.2013.05.014_bb0080) 2011; 49 Stein (10.1016/j.bone.2013.05.014_bb0130) 2010; 25 Gao (10.1016/j.bone.2013.05.014_bb0150) 2008; 26 Guo (10.1016/j.bone.2013.05.014_bb0115) 1997; 12 Nishiyama (10.1016/j.bone.2013.05.014_bb0075) 2010; 46 Bonnet (10.1016/j.bone.2013.05.014_bb0085) 2009; 36 Bouxsein (10.1016/j.bone.2013.05.014_bb0005) 2010; 25 Waarsing (10.1016/j.bone.2013.05.014_bb0010) 2004; 34 |
References_xml | – volume: 34 start-page: 1587 year: 2006 end-page: 1599 ident: bb0070 article-title: Evaluation of three-dimensional image registration methodologies for in vivo micro-computed tomography publication-title: Ann Biomed Eng contributor: fullname: Muller – volume: 46 start-page: 155 year: 2010 end-page: 161 ident: bb0075 article-title: Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration publication-title: Bone contributor: fullname: Boyd – volume: 25 start-page: 1468 year: 2010 end-page: 1486 ident: bb0005 article-title: Guidelines for assessment of bone microstructure in rodents using micro-computed tomography publication-title: J Bone Miner Res contributor: fullname: Muller – volume: 48 start-page: 433 year: 2011 end-page: 442 ident: bb0055 article-title: In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging publication-title: Bone contributor: fullname: Muller – volume: 24 start-page: 926 year: 2006 end-page: 935 ident: bb0045 article-title: Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats publication-title: J Orthop Res contributor: fullname: Weinans – volume: 25 start-page: 1325 year: 2007 end-page: 1332 ident: bb0025 article-title: No effects of in vivo micro-CT radiation on structural parameters and bone marrow cells in proximal tibia of Wistar rats detected after eight weekly scans publication-title: J Orthop Res contributor: fullname: Huiskes – volume: 23 start-page: 2048 year: 2008 end-page: 2059 ident: bb0040 article-title: Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice publication-title: J Bone Miner Res contributor: fullname: Boyd – volume: 35 start-page: 1375 year: 2004 end-page: 1382 ident: bb0090 article-title: The effect of microcomputed tomography scanning and reconstruction voxel size on the accuracy of stereological measurements in human cancellous bone publication-title: Bone contributor: fullname: Yeni – volume: 82 start-page: 202 year: 2008 end-page: 211 ident: bb0015 article-title: Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized Wistar rats assessed by in vivo micro-computed tomography publication-title: Calcif Tissue Int contributor: fullname: Huiskes – volume: 26 start-page: 164 year: 2008 end-page: 173 ident: bb0150 article-title: Monomodal image registration using mutual information based methods publication-title: Image Vis Comput contributor: fullname: Lin – volume: 25 start-page: 2296 year: 2010 end-page: 2305 ident: bb0130 article-title: Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures publication-title: J Bone Miner Res contributor: fullname: McMahon – volume: 27 start-page: 433 year: 1994 end-page: 444 ident: bb0120 article-title: A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stress publication-title: J Biomech contributor: fullname: Kikuchi – year: 2005 ident: bb0105 article-title: Consortium tIS. The ITK software guide contributor: fullname: Cates – volume: 12 start-page: 185 year: 1997 end-page: 196 ident: bb0115 article-title: Is trabecular bone tissue different from cortical bone tissue? publication-title: Forma contributor: fullname: Goldstein – volume: 21 start-page: 554 year: 1997 end-page: 566 ident: bb0145 article-title: Comparison and evaluation of retrospective intermodality brain image registration techniques publication-title: J Comput Assist Tomogr contributor: fullname: Kessler – volume: 3 start-page: 307 year: 2001 end-page: 333 ident: bb0065 article-title: Biomechanics of trabecular bone publication-title: Annu Rev Biomed Eng contributor: fullname: Yeh – volume: 36 start-page: 1286 year: 2009 end-page: 1297 ident: bb0085 article-title: Assessment of trabecular bone microarchitecture by two different x-ray microcomputed tomographs: a comparative study of the rat distal tibia using Skyscan and Scanco devices publication-title: Med Phys contributor: fullname: Benhamou – volume: 49 start-page: 1340 year: 2011 end-page: 1350 ident: bb0050 article-title: Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry publication-title: Bone contributor: fullname: Muller – volume: 25 start-page: 746 year: 2010 end-page: 756 ident: bb0110 article-title: High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone publication-title: J Bone Miner Res contributor: fullname: Bilezikian – volume: 21 start-page: 1161 year: 2010 end-page: 1169 ident: bb0135 article-title: Assessing forearm fracture risk in postmenopausal women publication-title: Osteoporos Int contributor: fullname: van Lenthe – volume: 39 start-page: 854 year: 2006 end-page: 862 ident: bb0030 article-title: Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography publication-title: Bone contributor: fullname: Gasser – volume: 24 start-page: 137 year: 1997 end-page: 154 ident: bb0095 article-title: Alignment by maximization of mutual information publication-title: Int J Comput Vis contributor: fullname: Wells – start-page: 263 year: 1995 end-page: 274 ident: bb0100 article-title: Automated multi-modality image registration based on information theory publication-title: Information processing in medical imaging contributor: fullname: Marchal – volume: 6 start-page: 413 year: 1998 end-page: 420 ident: bb0060 article-title: Assessment of cancellous bone mechanical properties from micro-FE models based on micro-CT, pQCT and MR images publication-title: Technol Health Care contributor: fullname: Laib – volume: 42 start-page: 1203 year: 2008 end-page: 1213 ident: bb0125 article-title: Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method publication-title: Bone contributor: fullname: Boyd – year: 2008 ident: bb0035 article-title: Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT contributor: fullname: Boyd – volume: 19 start-page: 175 year: 2000 end-page: 185 ident: bb0160 article-title: Semiautomatic 3-D image registration as applied to interventional MRI liver cancer treatment publication-title: IEEE Trans Med Imaging contributor: fullname: Wilson – volume: 49 start-page: 580 year: 2011 end-page: 587 ident: bb0080 article-title: MicroCT morphometry analysis of mouse cancellous bone: intra- and inter-system reproducibility publication-title: Bone contributor: fullname: Tetradis – volume: 27 start-page: 1521 year: 2009 end-page: 1527 ident: bb0020 article-title: Comparison of bone loss induced by ovariectomy and neurectomy in rats analyzed by in vivo micro-CT publication-title: J Orthop Res contributor: fullname: Huiskes – volume: 46 start-page: 1030 year: 2010 end-page: 1037 ident: bb0140 article-title: Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in postmenopausal women publication-title: Bone contributor: fullname: Delmas – volume: 18 start-page: 404 year: 1999 end-page: 418 ident: bb0155 article-title: Registration of stereo and temporal images of the retina publication-title: IEEE Trans Med Imaging contributor: fullname: van Saarloos – volume: 34 start-page: 163 year: 2004 end-page: 169 ident: bb0010 article-title: Detecting and tracking local changes in the tibiae of individual rats: a novel method to analyse longitudinal in vivo micro-CT data publication-title: Bone contributor: fullname: De Clerck – volume: 34 start-page: 163 year: 2004 ident: 10.1016/j.bone.2013.05.014_bb0010 article-title: Detecting and tracking local changes in the tibiae of individual rats: a novel method to analyse longitudinal in vivo micro-CT data publication-title: Bone doi: 10.1016/j.bone.2003.08.012 contributor: fullname: Waarsing – volume: 46 start-page: 1030 year: 2010 ident: 10.1016/j.bone.2013.05.014_bb0140 article-title: Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in postmenopausal women publication-title: Bone doi: 10.1016/j.bone.2009.12.015 contributor: fullname: Vilayphiou – volume: 12 start-page: 185 year: 1997 ident: 10.1016/j.bone.2013.05.014_bb0115 article-title: Is trabecular bone tissue different from cortical bone tissue? publication-title: Forma contributor: fullname: Guo – volume: 6 start-page: 413 year: 1998 ident: 10.1016/j.bone.2013.05.014_bb0060 article-title: Assessment of cancellous bone mechanical properties from micro-FE models based on micro-CT, pQCT and MR images publication-title: Technol Health Care doi: 10.3233/THC-1998-65-613 contributor: fullname: van Rietbergen – year: 2008 ident: 10.1016/j.bone.2013.05.014_bb0035 contributor: fullname: Campbell – volume: 48 start-page: 433 year: 2011 ident: 10.1016/j.bone.2013.05.014_bb0055 article-title: In vivo micro-computed tomography allows direct three-dimensional quantification of both bone formation and bone resorption parameters using time-lapsed imaging publication-title: Bone doi: 10.1016/j.bone.2010.10.007 contributor: fullname: Schulte – volume: 27 start-page: 433 year: 1994 ident: 10.1016/j.bone.2013.05.014_bb0120 article-title: A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stress publication-title: J Biomech doi: 10.1016/0021-9290(94)90019-1 contributor: fullname: Hollister – start-page: 263 year: 1995 ident: 10.1016/j.bone.2013.05.014_bb0100 article-title: Automated multi-modality image registration based on information theory contributor: fullname: Collignon – volume: 23 start-page: 2048 year: 2008 ident: 10.1016/j.bone.2013.05.014_bb0040 article-title: Postpubertal architectural developmental patterns differ between the L3 vertebra and proximal tibia in three inbred strains of mice publication-title: J Bone Miner Res doi: 10.1359/jbmr.080808 contributor: fullname: Buie – volume: 42 start-page: 1203 year: 2008 ident: 10.1016/j.bone.2013.05.014_bb0125 article-title: Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method publication-title: Bone doi: 10.1016/j.bone.2008.01.017 contributor: fullname: Macneil – volume: 25 start-page: 1468 year: 2010 ident: 10.1016/j.bone.2013.05.014_bb0005 article-title: Guidelines for assessment of bone microstructure in rodents using micro-computed tomography publication-title: J Bone Miner Res doi: 10.1002/jbmr.141 contributor: fullname: Bouxsein – volume: 49 start-page: 1340 year: 2011 ident: 10.1016/j.bone.2013.05.014_bb0050 article-title: Mouse tail vertebrae adapt to cyclic mechanical loading by increasing bone formation rate and decreasing bone resorption rate as shown by time-lapsed in vivo imaging of dynamic bone morphometry publication-title: Bone doi: 10.1016/j.bone.2011.08.035 contributor: fullname: Lambers – volume: 18 start-page: 404 year: 1999 ident: 10.1016/j.bone.2013.05.014_bb0155 article-title: Registration of stereo and temporal images of the retina publication-title: IEEE Trans Med Imaging doi: 10.1109/42.774168 contributor: fullname: Ritter – volume: 34 start-page: 1587 year: 2006 ident: 10.1016/j.bone.2013.05.014_bb0070 article-title: Evaluation of three-dimensional image registration methodologies for in vivo micro-computed tomography publication-title: Ann Biomed Eng doi: 10.1007/s10439-006-9168-7 contributor: fullname: Boyd – volume: 19 start-page: 175 year: 2000 ident: 10.1016/j.bone.2013.05.014_bb0160 article-title: Semiautomatic 3-D image registration as applied to interventional MRI liver cancer treatment publication-title: IEEE Trans Med Imaging doi: 10.1109/42.845176 contributor: fullname: Carrillo – volume: 27 start-page: 1521 year: 2009 ident: 10.1016/j.bone.2013.05.014_bb0020 article-title: Comparison of bone loss induced by ovariectomy and neurectomy in rats analyzed by in vivo micro-CT publication-title: J Orthop Res doi: 10.1002/jor.20913 contributor: fullname: Brouwers – volume: 26 start-page: 164 year: 2008 ident: 10.1016/j.bone.2013.05.014_bb0150 article-title: Monomodal image registration using mutual information based methods publication-title: Image Vis Comput doi: 10.1016/j.imavis.2006.08.002 contributor: fullname: Gao – volume: 82 start-page: 202 year: 2008 ident: 10.1016/j.bone.2013.05.014_bb0015 article-title: Bone degeneration and recovery after early and late bisphosphonate treatment of ovariectomized Wistar rats assessed by in vivo micro-computed tomography publication-title: Calcif Tissue Int doi: 10.1007/s00223-007-9084-3 contributor: fullname: Brouwers – volume: 24 start-page: 137 year: 1997 ident: 10.1016/j.bone.2013.05.014_bb0095 article-title: Alignment by maximization of mutual information publication-title: Int J Comput Vis doi: 10.1023/A:1007958904918 contributor: fullname: Viola – volume: 3 start-page: 307 year: 2001 ident: 10.1016/j.bone.2013.05.014_bb0065 article-title: Biomechanics of trabecular bone publication-title: Annu Rev Biomed Eng doi: 10.1146/annurev.bioeng.3.1.307 contributor: fullname: Keaveny – volume: 49 start-page: 580 year: 2011 ident: 10.1016/j.bone.2013.05.014_bb0080 article-title: MicroCT morphometry analysis of mouse cancellous bone: intra- and inter-system reproducibility publication-title: Bone doi: 10.1016/j.bone.2011.05.013 contributor: fullname: Verdelis – volume: 21 start-page: 554 year: 1997 ident: 10.1016/j.bone.2013.05.014_bb0145 article-title: Comparison and evaluation of retrospective intermodality brain image registration techniques publication-title: J Comput Assist Tomogr doi: 10.1097/00004728-199707000-00007 contributor: fullname: West – volume: 24 start-page: 926 year: 2006 ident: 10.1016/j.bone.2013.05.014_bb0045 article-title: Bone loss dynamics result in trabecular alignment in aging and ovariectomized rats publication-title: J Orthop Res doi: 10.1002/jor.20063 contributor: fullname: Waarsing – volume: 36 start-page: 1286 year: 2009 ident: 10.1016/j.bone.2013.05.014_bb0085 article-title: Assessment of trabecular bone microarchitecture by two different x-ray microcomputed tomographs: a comparative study of the rat distal tibia using Skyscan and Scanco devices publication-title: Med Phys doi: 10.1118/1.3096605 contributor: fullname: Bonnet – year: 2005 ident: 10.1016/j.bone.2013.05.014_bb0105 contributor: fullname: lbanez – volume: 25 start-page: 746 year: 2010 ident: 10.1016/j.bone.2013.05.014_bb0110 article-title: High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone publication-title: J Bone Miner Res doi: 10.1002/jbmr.92 contributor: fullname: Liu – volume: 25 start-page: 2296 year: 2010 ident: 10.1016/j.bone.2013.05.014_bb0130 article-title: Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures publication-title: J Bone Miner Res doi: 10.1002/jbmr.152 contributor: fullname: Stein – volume: 21 start-page: 1161 year: 2010 ident: 10.1016/j.bone.2013.05.014_bb0135 article-title: Assessing forearm fracture risk in postmenopausal women publication-title: Osteoporos Int doi: 10.1007/s00198-009-1047-2 contributor: fullname: Melton – volume: 46 start-page: 155 year: 2010 ident: 10.1016/j.bone.2013.05.014_bb0075 article-title: Reproducibility of bone micro-architecture measurements in rodents by in vivo micro-computed tomography is maximized with three-dimensional image registration publication-title: Bone doi: 10.1016/j.bone.2009.09.023 contributor: fullname: Nishiyama – volume: 35 start-page: 1375 year: 2004 ident: 10.1016/j.bone.2013.05.014_bb0090 article-title: The effect of microcomputed tomography scanning and reconstruction voxel size on the accuracy of stereological measurements in human cancellous bone publication-title: Bone doi: 10.1016/j.bone.2004.09.007 contributor: fullname: Kim – volume: 39 start-page: 854 year: 2006 ident: 10.1016/j.bone.2013.05.014_bb0030 article-title: Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography publication-title: Bone doi: 10.1016/j.bone.2006.04.017 contributor: fullname: Boyd – volume: 25 start-page: 1325 year: 2007 ident: 10.1016/j.bone.2013.05.014_bb0025 article-title: No effects of in vivo micro-CT radiation on structural parameters and bone marrow cells in proximal tibia of Wistar rats detected after eight weekly scans publication-title: J Orthop Res doi: 10.1002/jor.20439 contributor: fullname: Brouwers |
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Snippet | Abstract In the recent decade, in vivo μCT scanners have become available to monitor temporal changes in rodent bone in response to diseases and treatments. We... In the recent decade, in vivo μCT scanners have become available to monitor temporal changes in rodent bone in response to diseases and treatments. We... |
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SubjectTerms | 3D image registration Animal models/rodent Animals Biological and medical sciences Biomechanical Phenomena Bone Density - physiology Female Finite Element Analysis Fundamental and applied biological sciences. Psychology Imaging, Three-Dimensional In vivo μCT Investigative techniques, diagnostic techniques (general aspects) Medical sciences Orthopedics Osteoarticular system. Muscles Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Sprague-Dawley Reproducibility of Results Tibia - anatomy & histology Tibia - diagnostic imaging Tibia - physiology Time Factors Trabecular bone microstructure Vertebrates: anatomy and physiology, studies on body, several organs or systems X-Ray Microtomography |
Title | 3D image registration is critical to ensure accurate detection of longitudinal changes in trabecular bone density, microstructure, and stiffness measurements in rat tibiae by in vivo microcomputed tomography (μCT) |
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