A network pharmacology approach to investigate the mechanism of Shuxuening injection in the treatment of ischemic stroke

• Published in: Journal of ethnopharmacology Vol. 257; no. NA; p. 112891
• Main Authors: Cui, Qian, Zhang, Yu-liang, Ma, Yu-hui, Yu, Hao-yu, Zhao, Xin-zhe, Zhang, Li-hui, Ge, Shao-qin, Zhang, Guo-wei, Qin, Xiu-de
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 15.07.2020
• Subjects: absorption; active ingredients; animal experimentation; Animal experiments; Animals; Anti-Inflammatory Agents - administration & dosage; Antioxidants - administration & dosage; apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; brain; Brain - drug effects; Brain - metabolism; Brain - pathology; China; chlorides; computer simulation; Databases, Genetic; Disease Models, Animal; Drugs, Chinese Herbal - administration & dosage; endothelial nitric oxide synthase; excretion; Gene Expression Regulation; gene ontology; Gene Regulatory Networks; genes; Genetic Association Studies; Ginkgo biloba; Ginkgo biloba extract; herbal medicines; infarction; Infarction, Middle Cerebral Artery - drug therapy; Infarction, Middle Cerebral Artery - genetics; Infarction, Middle Cerebral Artery - metabolism; Infarction, Middle Cerebral Artery - pathology; inflammation; Inflammation Mediators - metabolism; Injections, Intravenous; Ischemic stroke; Ischemic Stroke - drug therapy; Ischemic Stroke - genetics; Ischemic Stroke - metabolism; Ischemic Stroke - pathology; leaves; messenger RNA; Molecular docking; Molecular Docking Simulation; Network pharmacology; neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuroprotective Agents - administration & dosage; Oriental traditional medicine; oxidative stress; Oxidative Stress - drug effects; pharmacology; protein content; Protein Interaction Maps; protein synthesis; protein-protein interactions; quantitative polymerase chain reaction; rats; Rats, Sprague-Dawley; reverse transcriptase polymerase chain reaction; Shuxuening injection; Signal Transduction; staining; stroke; Systems Biology; tetrazolium; Western blotting; China; Shuxuening injection; Network pharmacology; Ischemic stroke; Animal experiments; Ginkgo biloba extract; Molecular docking

Shuxuening injection (SXNI), a popular herbal medicine, is an extract of Ginkgo biloba leaves (GBE), and is used to treat ischemic stroke (IS) in China. However, its specific active ingredients and molecular mechanisms in IS remain unclear. Aim of the study: The purpose of the research is to identif...