A network pharmacology approach to investigate the mechanism of Shuxuening injection in the treatment of ischemic stroke - Cui, Qian; Zhang, Yu-liang; Ma, Yu-hui; Yu, Hao-yu; Zhao, Xin-zhe; Zhang, Li-hui; Ge, Shao-qin; Zhang, Guo-wei; Qin, Xiu-de (Journal of ethnopharmacology, 2020)
Keywords: absorption; active ingredients; animal experimentation; Animal experiments; Animals; Anti-Inflammatory Agents - administration & dosage; Antioxidants - administration & dosage; apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; brain; Brain - drug effects; Brain - metabolism; Brain - pathology; China; chlorides; computer simulation; Databases, Genetic; Disease Models, Animal; Drugs, Chinese Herbal - administration & dosage; endothelial nitric oxide synthase; excretion; Gene Expression Regulation; gene ontology; Gene Regulatory Networks; genes; Genetic Association Studies; Ginkgo biloba; Ginkgo biloba extract; herbal medicines; infarction; Infarction, Middle Cerebral Artery - drug therapy; Infarction, Middle Cerebral Artery - genetics; Infarction, Middle Cerebral Artery - metabolism; Infarction, Middle Cerebral Artery - pathology; inflammation; Inflammation Mediators - metabolism; Injections, Intravenous; Ischemic stroke; Ischemic Stroke - drug therapy; Ischemic Stroke - genetics; Ischemic Stroke - metabolism; Ischemic Stroke - pathology; leaves; messenger RNA; Molecular docking; Molecular Docking Simulation; Network pharmacology; neurons; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuroprotective Agents - administration & dosage; Oriental traditional medicine; oxidative stress; Oxidative Stress - drug effects; pharmacology; protein content; Protein Interaction Maps; protein synthesis; protein-protein interactions; quantitative polymerase chain reaction; rats; Rats, Sprague-Dawley; reverse transcriptase polymerase chain reaction; Shuxuening injection; Signal Transduction; staining; stroke; Systems Biology; tetrazolium; Western blotting; China; Shuxuening injection; Network pharmacology; Ischemic stroke; Animal experiments; Ginkgo biloba extract; Molecular docking