Design of Biodegradable Nanoparticles for Oral Delivery of Doxorubicin: In vivo Pharmacokinetics and Toxicity Studies in Rats

• Published in: Pharmaceutical research Vol. 26; no. 3; pp. 492 - 501
• Main Authors: Kalaria, D. R, Sharma, G, Beniwal, V, Ravi Kumar, M. N. V
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.03.2009; Springer US; Springer; Springer Nature B.V
• Subjects: administration & dosage; Administration, Oral; Animals; Antibiotics; Antibiotics, Antineoplastic; Antibiotics, Antineoplastic - administration & dosage; Antibiotics, Antineoplastic - pharmacokinetics; Antibiotics, Antineoplastic - toxicity; Bioavailability; Biochemistry; Biocompatible Materials; Biocompatible Materials - chemistry; Biodegradable materials; Biological and medical sciences; Biological Availability; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Calorimetry, Differential Scanning; cardiotoxicity; chemistry; Doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - pharmacokinetics; Doxorubicin - toxicity; Drug Carriers; Drug Carriers - chemistry; Drug Design; Drug Stability; Female; General pharmacology; Hydrogen-Ion Concentration; Lactic Acid; Lactic Acid - chemistry; Medical Law; Medical sciences; Nanoparticles; Nanoparticles - chemistry; oral delivery; oxidative stress; Parasitic diseases; Particle Size; Pharmaceutical sciences; Pharmaceutical technology. Pharmaceutical industry; pharmacokinetics; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacy; Polyglycolic Acid; Polyglycolic Acid - chemistry; Rats; Rats, Sprague-Dawley; Research Paper; Solubility; Surface Properties; Toxicity; X-Ray Diffraction; cardiotoxicity; bioavailability; oxidative stress; oral delivery; Antineoplastic agent; Oxidative stress; Rat; Biodegradability; Nanoparticle; Toxicity; Cardiovascular disease; Doxorubicin; Design; Isomerases; Microparticle; DNA topoisomerase (ATP-hydrolysing); Pharmaceutical technology; Enzyme; Rodentia; Oral administration; Enzyme inhibitor; Topoisomerase II inhibitor; Bioavailability; In vivo; Vertebrata; Antibiotic; Mammalia; Animal; Anthracyclins; Pharmacokinetics

Purpose Doxorubicin, a potent anticancer drug associated with cardiotoxicity and low oral bioavailability, was loaded into nanoparticles with a view to improve its performance. Methods Doxorubicin loaded PLGA nanoparticles were prepared by a double emulsion method. The pH dependent stability of nano...