Air pollution impairs recovery and tissue remodeling in a murine model of acute lung injury

• Published in: Scientific reports Vol. 10; no. 1; p. 15314
• Main Authors: de Souza Xavier Costa, Natália, Ribeiro Júnior, Gabriel, dos Santos Alemany, Adair Aparecida, Belotti, Luciano, Schalch, Alexandre Santos, Cavalcante, Marcela Frota, Ribeiro, Susan, Veras, Mariana Matera, Kallás, Esper Georges, Saldiva, Paulo Hilário Nascimento, Dolhnikoff, Marisa, Ferraz da Silva, Luiz Fernando
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.09.2020
• Subjects: 631/1647/767/1424; 631/250/256/2516; 631/443/1784; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Air Pollution - adverse effects; Animals; Bronchoalveolar Lavage Fluid; Cytokines - metabolism; Disease Models, Animal; Humanities and Social Sciences; Inflammation - metabolism; Inflammation - pathology; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Lung - metabolism; Lung - pathology; Male; Mice; Mice, Inbred BALB C; multidisciplinary; Particulate Matter - adverse effects; Respiratory Distress Syndrome - metabolism; Respiratory Distress Syndrome - pathology; Science; Science (multidisciplinary)

Evidence regarding the impact of air pollution on acute respiratory distress syndrome (ARDS) is limited, and most studies focus on ARDS onset. Our study aimed to evaluate whether exposure to fine particulate matter interferes with lung recovery and remodeling in a murine model of acute lung injury....