Age-related biochemical dysfunction in 6-OHDA model rats subject to induced- endurance exercise

• Published in: Archives of gerontology and geriatrics Vol. 98; p. 104554
• Main Authors: Rezaee, Zeinab, Marandi, Sayed Mohammad, Esfarjani, Fahimeh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2022
• Subjects: aging; Animals; Apomorphine - pharmacology; Bdnf; Corpus Striatum; Disease Models, Animal; dopamine; Exercise Therapy; Humans; neurodegeneration; Oxidopamine - toxicity; Parkinson Disease; Rats; running; Tfam; running; neurodegeneration; Tfam; aging; Bdnf; dopamine

•6-OHDA injection impairs mitochondrial and behavioral function of the subjects groups•Dysfunctions caused by Parkinson's disease are greater in old rats•Endurance treadmill exercise reduces the neurochemical deficit after 6-OHDA lesion•The neuroprotective effects of exercise are greater in you...