Regional alterations in renal haemodynamics and oxygenation: a role in contrast medium-induced nephropathy

• Published in: Nephrology, dialysis, transplantation Vol. 20; no. suppl-1; pp. i6 - i11
• Main Authors: Heyman, Samuel N., Rosenberger, Christian, Rosen, Seymour
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Oxford University Press 01.02.2005; Oxford Publishing Limited (England)
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Associated diseases and complications; Biological and medical sciences; Contrast Media - adverse effects; Diabetes. Impaired glucose tolerance; Emergency and intensive care: renal failure. Dialysis management; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; haemodynamics; Hemodynamics; Humans; Hypoxia - complications; Intensive care medicine; Kidney Diseases - chemically induced; Kidney Diseases - etiology; Kidney Diseases - metabolism; Kidney Diseases - physiopathology; Kidney Medulla - metabolism; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Oxygen - metabolism; Renal Circulation; Renal failure; Kidney disease; Extrarenal dialysis; Urinary system disease; Nephropathy; Hemodialysis; Renal failure; Hemodynamics; Oxygenation; haemodynamics

Although the nature of renal dysfunction following the use of iodinated radiological contrast agents has long been a matter of dispute, tubular hypoxic injury does play a central role as indicated by both clinical observations and experimental animal models. Indeed, radiocontrast agents induce renal...