Hydrogels with tunable mechanical plasticity regulate endothelial cell outgrowth in vasculogenesis and angiogenesis

• Published in: Nature communications Vol. 14; no. 1; pp. 8307 - 16
• Main Authors: Wei, Zhao, Lei, Meng, Wang, Yaohui, Xie, Yizhou, Xie, Xueyong, Lan, Dongwei, Jia, Yuanbo, Liu, Jingyi, Ma, Yufei, Cheng, Bo, Gerecht, Sharon, Xu, Feng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 14/1; 14/19; 631/57/2268; 639/301/923/1027; 64/60; 692/4019/592/16; Adherens junctions; Angiogenesis; Cell Differentiation; Cell interactions; Collagen - metabolism; Contractility; Endothelial cells; Endothelial Cells - metabolism; Extracellular matrix; Focal adhesion kinase; Humanities and Social Sciences; Hyaluronic acid; Hydrogels; Hydrogels - chemistry; In vivo methods and tests; Kinases; Lumens; Mathematical analysis; multidisciplinary; Neovascularization, Physiologic - physiology; Plastic properties; Plasticity; Science; Science (multidisciplinary)

The endothelial cell (EC) outgrowth in both vasculogenesis and angiogenesis starts with remodeling surrounding matrix and proceeds with the crosstalk between cells for the multicellular vasculature formation. The mechanical plasticity of matrix, defined as the ability to permanently deform by extern...