NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte‐to‐Embryo Transition

• Published in: Advanced science Vol. 10; no. 27; pp. e2301940 - n/a
• Main Authors: Meng, Tie‐Gang, Guo, Jia‐Ni, Zhu, Liu, Yin, Yike, Wang, Feng, Han, Zhi‐Ming, Lei, Lei, Ma, Xue‐Shan, Xue, Yue, Yue, Wei, Nie, Xiao‐Qing, Zhao, Zheng‐Hui, Zhang, Hong‐Yong, Sun, Si‐Min, Ouyang, Ying‐Chun, Hou, Yi, Schatten, Heide, Ju, Zhenyu, Ou, Xiang‐Hong, Wang, Zhen‐Bo, Wong, Catherine C. L., Li, Zhonghan, Sun, Qing‐Yuan
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.09.2023; John Wiley and Sons Inc; Wiley
• Subjects: adenosine triphosphate (ATP); calcium homeostasis; CRISPR; DNA methylation; early embryonic development; Embryos; Females; Genes; Homeostasis; Infertility; Localization; maternal effect genes; Mitochondria; Mutation; NCLX; Ovaries; Ovulation; Proteins; Sperm; Uterus; NLRP14; maternal effect genes; early embryonic development; NCLX; UHRF1; adenosine triphosphate (ATP); mitochondria; calcium homeostasis

Sperm‐induced Ca 2+ rise is critical for driving oocyte activation and subsequent embryonic development, but little is known about how lasting Ca 2+ oscillations are regulated. Here it is shown that NLRP14, a maternal effect factor, is essential for keeping Ca 2+ oscillations and early embryonic dev...