N-Heterocyclic carbene-catalyzed enantioselective synthesis of planar-chiral cyclophanes via dynamic kinetic resolution

• Published in: Nature communications Vol. 15; no. 1; pp. 2338 - 11
• Main Authors: Li, Jiayan, Dong, Ziyang, Chen, Yang, Yang, Zhanhui, Yan, Xinen, Wang, Meng, Li, Chenyang, Zhao, Changgui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 140/131; 140/146; 140/58; 639/638/403/933; 639/638/77/883; 639/638/77/888; Aromatic compounds; Asymmetry; Carbenes; Catalysis; Chemical synthesis; Chemistry; Drug discovery; Enantiomers; Enzymes; Humanities and Social Sciences; Inclusion; multidisciplinary; Optimization; Science; Science (multidisciplinary); Solvents; Substrates

Planar-chiral cyclophanes have gained considerable concerns for drug discovery due to their unique conformational strain and 3D structure. However, the enantioselective synthesis of planar-chiral cyclophanes is a long-standing challenge for the synthetic community. We herein describe an N-heterocycl...