Identification of neoantigens for individualized therapeutic cancer vaccines

• Published in: Nature reviews. Drug discovery Vol. 21; no. 4; pp. 261 - 282
• Main Authors: Lang, Franziska, Schrörs, Barbara, Löwer, Martin, Türeci, Özlem, Sahin, Ugur
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Nature Publishing Group
• Subjects: 631/114/2413; 631/67/1857; 631/67/69; Antigens, Neoplasm - genetics; Biomedical and Life Sciences; Biomedicine; Biotechnology; Cancer; Cancer Research; Cancer Vaccines; Humans; Immunotherapy; Medicinal Chemistry; Molecular Medicine; Mutation; Neoplasms - genetics; Neoplasms - therapy; Pharmacology/Toxicology; Review Article; T-Lymphocytes; Vaccines

Somatic mutations in cancer cells can generate tumour-specific neoepitopes, which are recognized by autologous T cells in the host. As neoepitopes are not subject to central immune tolerance and are not expressed in healthy tissues, they are attractive targets for therapeutic cancer vaccines. Becaus...