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Keywords: 631/326/596/2555; 631/326/596/4130; 64/110; 82/51; ACE2; Angiotensin-converting enzyme 2; Animal models; Animals; Animals, Genetically Modified; Clinical isolates; Coronaviruses; COVID-19; COVID-19 - virology; Cricetinae; Fitness; Genetic Fitness - genetics; Genetic Fitness - physiology; Hamsters; Humanities and Social Sciences; Humans; Mesocricetus - virology; Mice; Mice, Transgenic; multidisciplinary; Mutation; Pathogenicity; Pathogens; Rodentia - virology; Rodents; SARS-CoV-2 - classification; SARS-CoV-2 - genetics; SARS-CoV-2 - pathogenicity; SARS-CoV-2 - physiology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike protein; Transgenic mice; Virulence; Viruses; United States--US; Japan