Dual origins of measured phase-amplitude coupling reveal distinct neural mechanisms underlying episodic memory in the human cortex

• Published in: NeuroImage (Orlando, Fla.) Vol. 148; pp. 148 - 159
• Main Authors: Vaz, Alex P., Yaffe, Robert B., Wittig, John H., Inati, Sara K., Zaghloul, Kareem A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2017; Elsevier Limited
• Subjects: Adult; Algorithms; Association; Brain Mapping; Cerebral Cortex - physiology; Drug Resistant Epilepsy - diagnostic imaging; Drug Resistant Epilepsy - surgery; Electrodes; Electrodes, Implanted; Electroencephalography; Entropy; Female; Humans; iEEG; Male; Memory, Episodic; Nested oscillations; Psychomotor Performance - physiology; Sharp waveforms; Software; Wavelet Analysis; Nested oscillations; Sharp waveforms; iEEG

Phase-amplitude coupling (PAC) is hypothesized to coordinate neural activity, but its role in successful memory formation in the human cortex is unknown. Measures of PAC are difficult to interpret, however. Both increases and decreases in PAC have been linked to memory encoding, and PAC may arise du...