Tandem gene duplications contributed to high-level azole resistance in a rapidly expanding Candida tropicalis population

• Published in: Nature communications Vol. 14; no. 1; pp. 8369 - 18
• Main Authors: Fan, Xin, Dai, Rong-Chen, Zhang, Shu, Geng, Yuan-Yuan, Kang, Mei, Guo, Da-Wen, Mei, Ya-Ning, Pan, Yu-Hong, Sun, Zi-Yong, Xu, Ying-Chun, Gong, Jie, Xiao, Meng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 45/23; 45/47; 45/77; 45/88; 49; 631/181/457/649; 631/326/193/2541; 692/699/255/1672; Antifungal agents; Antifungal Agents - pharmacology; Azoles - pharmacology; Candida tropicalis; Candida tropicalis - genetics; Candidiasis; Clusters; Drug resistance; Drug Resistance, Fungal - genetics; Fungicides; Gene Duplication; Gene sequencing; Genomes; Humanities and Social Sciences; Microbial Sensitivity Tests; multidisciplinary; Multilocus Sequence Typing; Nucleotide sequence; Population genetics; Population studies; Science; Science (multidisciplinary); Whole genome sequencing; Yeast

Invasive diseases caused by the globally distributed commensal yeast Candida tropicalis are associated with mortality rates of greater than 50%. Notable increases of azole resistance have been observed in this species, particularly within Asia-Pacific regions. Here, we carried out a genetic populati...