The nonsteroidal mycoestrogen zearalenone and its five metabolites suppress LH secretion from the bovine anterior pituitary cells via the estradiol receptor GPR30 in vitro

• Published in: Theriogenology Vol. 84; no. 8; pp. 1342 - 1349
• Main Authors: Nakamura, Urara, Kadokawa, Hiroya
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2015
• Subjects: Animals; antagonists; anterior pituitary; Benzodioxoles - pharmacology; blood; Cattle; Cells, Cultured; cultured cells; cyclic AMP; Enterohepatic cycling; estradiol; estrogen receptors; Estrogens, Non-Steroidal - pharmacology; feeds; fungi; Fusarium; G-protein coupled receptors; G-protein–coupled estrogen receptor 1; gene expression; Gonadotrope; gonadotropin-releasing hormone; half life; humans; luteinizing hormone; Luteinizing Hormone - secretion; metabolites; Nongenomic effect; Pituitary Gland - drug effects; Pituitary Gland - secretion; Quinolines - pharmacology; Receptors, Estrogen - antagonists & inhibitors; Receptors, Estrogen - metabolism; Receptors, Estrogen - physiology; Ruminant; secretion; small cereal grains; urine; Zearalenone; Zeranol - analogs & derivatives; Zeranol - metabolism; Zeranol - pharmacology; Gonadotrope; Zearalenone; G-protein–coupled estrogen receptor 1; Enterohepatic cycling; Nongenomic effect; Ruminant

Picomolar concentrations of estradiol produce nongenomic suppression of GnRH-induced LH secretion from the anterior pituitary (AP) of cattle via G-protein–coupled receptor 30 (GPR30). Zearalenone (ZEN) is the nonsteroidal mycoestrogen produced by Fusarium fungi and has been detected in cereal grains...