KPNA2 promotes the progression of gastric cancer by regulating the alternative splicing of related genes

• Published in: Scientific reports Vol. 14; no. 1; pp. 17140 - 21
• Main Authors: Chen, Xia, Wei, Hui, Yue, Ailin, Zhang, Huiyun, Zheng, Ya, Sun, Weiming, Zhou, Yongning, Wang, Yuping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1504/1829; 692/4020; alpha Karyopherins - genetics; alpha Karyopherins - metabolism; Alternative Splicing; Cell growth; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Disease Progression; Exon skipping; Female; Gastric cancer; Gene Expression Regulation, Neoplastic; Gene regulation; Humanities and Social Sciences; Humans; Immune response; Immunization; Immunoprecipitation; KPNA2; Lymph nodes; Lymphatic Metastasis; Male; Metastases; Middle Aged; multidisciplinary; Ribonucleic acid; RNA; RNA-binding protein; Science; Science (multidisciplinary); Splicing factors; Splicing regulatory sequence; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Wound healing; Alternative splicing; Immunization; KPNA2; Gastric cancer; Splicing regulatory sequence

RNA-binding proteins (RBPs) play critical roles in genome regulation. In this study, we explored the latent function of KPNA2, which is an essential member of the RBP family, in the regulation of alternative splicing (AS) in gastric cancer (GC). We analyzed the role of KPNA2 in regulating differenti...