Safety evaluation of PEGylated MNPs and p-PEGylated MNPs in SD rats

• Published in: Scientific reports Vol. 13; no. 1; pp. 21501 - 16
• Main Authors: Wen, Hairuo, Huo, Guitao, Qin, Chao, Wu, Hui, Wang, Dan, Dan, Mo, Geng, Xingchao, Liu, Shujie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/1438; 631/154/570; 639/925/352; 639/925/357; 639/925/928; Animals; Diagnosis; DNA damage; Humanities and Social Sciences; Hyperthermia; Inflammation; Kidneys; Liver; Lymphocytes T; Magnetite Nanoparticles - therapeutic use; Medical diagnosis; multidisciplinary; Nanoparticles; Neoplasms; Oxidative stress; Polyethylene glycol; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Safety; Science; Science (multidisciplinary); Toxicity

Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the...