Safety evaluation of PEGylated MNPs and p-PEGylated MNPs in SD rats

Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 13; no. 1; pp. 21501 - 16
Main Authors Wen, Hairuo, Huo, Guitao, Qin, Chao, Wu, Hui, Wang, Dan, Dan, Mo, Geng, Xingchao, Liu, Shujie
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 06.12.2023
Nature Publishing Group
Nature Portfolio
Subjects
631/154/1438
631/154/570
639/925/352
639/925/357
639/925/928
Animals
Diagnosis
DNA damage
Humanities and Social Sciences
Hyperthermia
Inflammation
Kidneys
Liver
Lymphocytes T
Magnetite Nanoparticles - therapeutic use
Medical diagnosis
multidisciplinary
Nanoparticles
Neoplasms
Oxidative stress
Polyethylene glycol
Polyethylene Glycols
Rats
Rats, Sprague-Dawley
Safety
Science
Science (multidisciplinary)
Toxicity
Online AccessGet full text

Cover

Abstract Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported. In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD (Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation. We revealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylated MNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, but no related pathological change was found. Both MNPs are not mutagenic, while recoverable mild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrated a research approach for the non-clinical safety evaluation of nanoparticles. It also provided comprehensive valuable safety data for PEGylated and p-PEGylated MNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications in the cancer diagnosis and therapy.
AbstractList Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported. In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD (Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation. We revealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylated MNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, but no related pathological change was found. Both MNPs are not mutagenic, while recoverable mild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrated a research approach for the non-clinical safety evaluation of nanoparticles. It also provided comprehensive valuable safety data for PEGylated and p-PEGylated MNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications in the cancer diagnosis and therapy.
Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported. In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD (Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation. We revealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylated MNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, but no related pathological change was found. Both MNPs are not mutagenic, while recoverable mild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrated a research approach for the non-clinical safety evaluation of nanoparticles. It also provided comprehensive valuable safety data for PEGylated and p-PEGylated MNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications in the cancer diagnosis and therapy.
Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported. In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD (Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation. We revealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylated MNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, but no related pathological change was found. Both MNPs are not mutagenic, while recoverable mild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrated a research approach for the non-clinical safety evaluation of nanoparticles. It also provided comprehensive valuable safety data for PEGylated and p-PEGylated MNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications in the cancer diagnosis and therapy.Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported. In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD (Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation. We revealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylated MNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, but no related pathological change was found. Both MNPs are not mutagenic, while recoverable mild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrated a research approach for the non-clinical safety evaluation of nanoparticles. It also provided comprehensive valuable safety data for PEGylated and p-PEGylated MNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications in the cancer diagnosis and therapy.
Abstract Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported. In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD (Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation. We revealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylated MNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, but no related pathological change was found. Both MNPs are not mutagenic, while recoverable mild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrated a research approach for the non-clinical safety evaluation of nanoparticles. It also provided comprehensive valuable safety data for PEGylated and p-PEGylated MNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications in the cancer diagnosis and therapy.
ArticleNumber 21501
Author Qin, Chao
Wang, Dan
Dan, Mo
Geng, Xingchao
Huo, Guitao
Wen, Hairuo
Wu, Hui
Liu, Shujie
Author_xml – sequence: 1
  givenname: Hairuo
  surname: Wen
  fullname: Wen, Hairuo
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control
– sequence: 2
  givenname: Guitao
  surname: Huo
  fullname: Huo, Guitao
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control
– sequence: 3
  givenname: Chao
  surname: Qin
  fullname: Qin, Chao
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control
– sequence: 4
  givenname: Hui
  surname: Wu
  fullname: Wu, Hui
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control, China Pharmaceutical University
– sequence: 5
  givenname: Dan
  surname: Wang
  fullname: Wang, Dan
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control, China Pharmaceutical University
– sequence: 6
  givenname: Mo
  surname: Dan
  fullname: Dan, Mo
  email: dmo@cspc.cn
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control, State Key Laboratory of Novel Pharmaceutical Preparations and Excipients, CSPC Pharmaceutical Group Co., Ltd
– sequence: 7
  givenname: Xingchao
  surname: Geng
  fullname: Geng, Xingchao
  email: gengxch@nifdc.org.cn
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control
– sequence: 8
  givenname: Shujie
  surname: Liu
  fullname: Liu, Shujie
  email: shjliu1983@126.com
  organization: National Center for Safety Evaluation of Drugs, Key Laboratory of Beijing for Nonclinical Safety Evaluation Research of Drugs, National Institutes for Food and Drug Control, Center for Drug Evaluation, National Medical Products Administration
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38057444$$D View this record in MEDLINE/PubMed
BookMark eNp9kUtv1DAUhS1UREvpH2CBIrFhE_AzsZdoKKVSgUqFtXX9qjLKxIPtUM2_x52UgmZRb2xdfefce31eoqMpTh6h1wS_J5jJD5kToWSLKWu57Dlt756hE4q5aCmj9Oi_9zE6y3mN6xFUcaJeoGMmseg55ydodQPBl13jf8M4Qxni1MTQXJ9f7EYo3jVfv13nBibXbNuD4jA1N5-aBCW_Qs8DjNmfPdyn6Ofn8x-rL-3V94vL1cer1nIpSmugt44HA954RUSHueXUyQ4LrETwxnEebDAWTOBdrySR2HYMFPRBEm8pO0WXi6-LsNbbNGwg7XSEQe8LMd1qSGWwo9cdJVSqzhpHJackqN6Bww4bUlcnzFSvd4vXNsVfs89Fb4Zs_TjC5OOcdVUr1lMiRUXfHqDrOKepbnpPyV5ILmSl3jxQs9l49zje36-uAF0Am2LOyYdHhGB9H6leItU1Ur2PVN9VkTwQ2aHsYyoJhvFpKVukufaZbn36N_YTqj-svLJ4
CitedBy_id crossref_primary_10_1080_14728222_2024_2421756
crossref_primary_10_2147_IJN_S471734
Cites_doi 10.2147/IJN.S157293
10.1186/s11671-015-1100-3
10.1038/s41598-019-43188-5
10.1016/j.carbpol.2021.118871
10.1166/jbn.2015.1996
10.1186/s12868-017-0369-9
10.1002/smll.201502309
10.1002/adma.201304744
10.1038/nm1467
10.1016/j.jconrel.2006.01.005
10.1007/s00216-010-3977-0
10.1007/s11051-017-3943-2
10.1021/ja2081263
10.1002/smll.201200381
10.1039/C8NR03084G
10.1016/j.jfda.2014.01.005
10.1007/s40199-018-0215-3
10.2174/1568026614666140118203550
10.1166/jbn.2018.2640
10.3390/pharmaceutics3010001
10.1038/nnano.2016.168
10.1093/toxsci/kfn245
10.1007/s40544-022-0710-x
10.1016/j.nano.2018.01.014
10.3390/ijms24021358
10.1016/j.biomaterials.2012.06.016
10.1021/mp900143a
10.1186/s12951-021-01059-0
10.1038/nature06917
10.1016/j.nano.2010.04.003
10.2217/nnm.11.19
10.1016/j.envres.2015.09.030
10.1038/jcbfm.2009.192
10.1016/j.freeradbiomed.2012.07.011
10.1016/j.nano.2011.11.004
10.1166/jbn.2011.1264
ContentType Journal Article
Copyright The Author(s) 2023
2023. The Author(s).
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2023
– notice: 2023. The Author(s).
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88A
88E
88I
8FE
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2P
M7P
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
Q9U
7X8
DOA
DOI 10.1038/s41598-023-48742-w
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
Publicly Available Content Database
MEDLINE - Academic


CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2045-2322
EndPage 16
ExternalDocumentID oai_doaj_org_article_6212896cbd28421f97dad0d0b138013b
38057444
10_1038_s41598_023_48742_w
Genre Journal Article
GrantInformation_xml – fundername: Ministry of Science and Technology of the People's Republic of China
  grantid: 2018ZX09201017; 81401517
  funderid: http://dx.doi.org/10.13039/501100002855
– fundername: Ministry of Science and Technology of the People's Republic of China
  grantid: 2018ZX09201017
– fundername: Ministry of Science and Technology of the People's Republic of China
  grantid: 81401517
GroupedDBID 0R~
3V.
4.4
53G
5VS
7X7
88A
88E
88I
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
AAKDD
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
ADRAZ
AENEX
AEUYN
AFKRA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
DWQXO
EBD
EBLON
EBS
ESX
FYUFA
GNUQQ
GROUPED_DOAJ
GX1
HCIFZ
HH5
HMCUK
HYE
KQ8
LK8
M0L
M1P
M2P
M48
M7P
M~E
NAO
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RNT
RNTTT
RPM
SNYQT
UKHRP
AASML
AAYXX
AFPKN
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
AARCD
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
Q9U
7X8
PUEGO
ID FETCH-LOGICAL-c485t-ba7cd4fbaebe915604c42d8605095febd44fcfbcabf46798180c63a9a7f81ec23
IEDL.DBID 7X7
ISSN 2045-2322
IngestDate Wed Aug 27 00:25:22 EDT 2025
Fri Jul 11 06:48:59 EDT 2025
Wed Aug 13 09:13:16 EDT 2025
Wed Feb 19 02:06:35 EST 2025
Thu Apr 24 22:57:00 EDT 2025
Tue Jul 01 03:58:00 EDT 2025
Fri Feb 21 02:37:24 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2023. The Author(s).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c485t-ba7cd4fbaebe915604c42d8605095febd44fcfbcabf46798180c63a9a7f81ec23
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://www.proquest.com/docview/2898758458?pq-origsite=%requestingapplication%
PMID 38057444
PQID 2898758458
PQPubID 2041939
PageCount 16
ParticipantIDs doaj_primary_oai_doaj_org_article_6212896cbd28421f97dad0d0b138013b
proquest_miscellaneous_2899372185
proquest_journals_2898758458
pubmed_primary_38057444
crossref_primary_10_1038_s41598_023_48742_w
crossref_citationtrail_10_1038_s41598_023_48742_w
springer_journals_10_1038_s41598_023_48742_w
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-12-06
PublicationDateYYYYMMDD 2023-12-06
PublicationDate_xml – month: 12
  year: 2023
  text: 2023-12-06
  day: 06
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Scientific reports
PublicationTitleAbbrev Sci Rep
PublicationTitleAlternate Sci Rep
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Weinstein, Varallyay, Dosa (CR4) 2010; 30
Zeng, Jing, Hou (CR19) 2014; 26
Zanganeh, Hutter, Spitler (CR7) 2016; 11
Ichihara, Shimizu, Imoto (CR28) 2010; 3
Karlsson (CR37) 2010; 398
Fereshteh, Masoud (CR24) 2018; 26
Zhu, Wang, Feng (CR8) 2010; 10
Li, Wei, Gao, Lei (CR17) 2005; 17
Lee, Huh, Jun (CR2) 2007; 13
Liu, Jia, Qiao (CR6) 2009; 6
Shah, Dobrovolskaia (CR15) 2018; 14
Gómez-Vallejo, Puigivila, Plaza-García (CR5) 2018; 10
Zhu, Tian, Song (CR35) 2012; 8
Gao, Ma, Zhao (CR13) 2016; 12
Dwivedi, Tripathi, Ansari, Shanker, Das (CR31) 2011; 7
Yarjanli, Ghaedi, Esmaeili, Rahgozar, Zarrabi (CR39) 2017; 18
Ansari, Parveen, Ahmad (CR16) 2019; 9
Wang, Dan, Ji, Wu, Xu, Wen (CR20) 2018; 14
Zhu, Feng, Wang (CR10) 2009; 107
Ishida, Ichihara, Wang (CR29) 2006; 112
Sekhon, Kamboj (CR21) 2010; 6
Li, Ishdorj, Gibson (CR12) 2012; 53
Donini, Pettinella, Zanella (CR30) 2023; 24
Bardestani, Ebrahimpour, Esmaeili, Esmaeili (CR41) 2021; 19
Di Gioacchino, Petrarca, Lazzarin (CR14) 2011; 24
Lu, Chen, Ding (CR22) 2022; 277
Meunier, Coste, Olagnier (CR33) 2012; 8
Maurizi, Papa, Dumont, BouyerF, Vandroux (CR26) 2015; 11
Salunkhe, Khot, Pawar (CR3) 2014; 14
Jokerst, Lobovkina, Zare, Gambhir (CR25) 2011; 6
Mai, Hilt (CR38) 2017; 19
Yang, Kim, Kim, Choi (CR32) 2012; 33
Laverman, Carstens, Boerman (CR27) 2001; 298
Salimi, Sarkar, Fathi (CR11) 2018; 13
Wang, Zhai, Cheng (CR23) 2023; 11
Weissleder, Pittet (CR1) 2008; 452
Park, Oh, Lee (CR36) 2015; 143
Canivet, Denayer, Dubot, Garçon, Lo Guidice (CR9) 2021; 41
Fu, Xia, Hwang (CR40) 2014; 22
Jia, Zeng, Qiao (CR18) 2011; 133
Dai, Li, Liu, Liu, Zhang (CR34) 2015; 10
Z Li (48742_CR17) 2005; 17
L Maurizi (48742_CR26) 2015; 11
A Shah (48742_CR15) 2018; 14
A Bardestani (48742_CR41) 2021; 19
JV Jokerst (48742_CR25) 2011; 6
PD Dwivedi (48742_CR31) 2011; 7
Z Yarjanli (48742_CR39) 2017; 18
AB Salunkhe (48742_CR3) 2014; 14
HL Karlsson (48742_CR37) 2010; 398
E Meunier (48742_CR33) 2012; 8
R Weissleder (48742_CR1) 2008; 452
L Canivet (48742_CR9) 2021; 41
Q Jia (48742_CR18) 2011; 133
M Donini (48742_CR30) 2023; 24
BS Sekhon (48742_CR21) 2010; 6
Z Gao (48742_CR13) 2016; 12
Y Wang (48742_CR23) 2023; 11
T Mai (48742_CR38) 2017; 19
T Dai (48742_CR34) 2015; 10
PP Fu (48742_CR40) 2014; 22
MO Ansari (48742_CR16) 2019; 9
P Laverman (48742_CR27) 2001; 298
EJ Yang (48742_CR32) 2012; 33
S Liu (48742_CR6) 2009; 6
M Di Gioacchino (48742_CR14) 2011; 24
M Zhu (48742_CR35) 2012; 8
J Zeng (48742_CR19) 2014; 26
JH Lee (48742_CR2) 2007; 13
M Ichihara (48742_CR28) 2010; 3
L Li (48742_CR12) 2012; 53
EJ Park (48742_CR36) 2015; 143
MT Zhu (48742_CR8) 2010; 10
MT Zhu (48742_CR10) 2009; 107
D Wang (48742_CR20) 2018; 14
J Lu (48742_CR22) 2022; 277
D Fereshteh (48742_CR24) 2018; 26
V Gómez-Vallejo (48742_CR5) 2018; 10
T Ishida (48742_CR29) 2006; 112
S Zanganeh (48742_CR7) 2016; 11
JS Weinstein (48742_CR4) 2010; 30
M Salimi (48742_CR11) 2018; 13
References_xml – volume: 13
  start-page: 1483
  year: 2018
  end-page: 1493
  ident: CR11
  article-title: Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S157293
– volume: 10
  start-page: 434
  issue: 1
  year: 2015
  ident: CR34
  article-title: AMP-conjugated quantum dots: Low immunotoxicity both in vitro and in vivo
  publication-title: Nanoscale Res. Lett.
  doi: 10.1186/s11671-015-1100-3
– volume: 9
  start-page: 6912
  issue: 1
  year: 2019
  ident: CR16
  article-title: Evaluation of DNA interaction, genotoxicity and oxidative stress induced by iron oxide nanoparticles both in vitro and in vivo: Attenuation by thymoquinone
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-43188-5
– volume: 277
  year: 2022
  ident: CR22
  article-title: A 4arm-PEG macromolecule crosslinked chitosan hydrogels as antibacterial wound dressing
  publication-title: Carbohydrate Polym.
  doi: 10.1016/j.carbpol.2021.118871
– volume: 11
  start-page: 126
  year: 2015
  end-page: 36
  ident: CR26
  article-title: Influence of surface charge and polymer coating on internalization and biodistribution of polyethylene glycol-modified iron oxide nanoparticles
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2015.1996
– volume: 298
  start-page: 607
  issue: 2
  year: 2001
  end-page: 612
  ident: CR27
  article-title: Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection
  publication-title: J. PharmacolExpTher.
– volume: 18
  start-page: 51
  issue: 1
  year: 2017
  ident: CR39
  article-title: Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation
  publication-title: BMC Neurosci.
  doi: 10.1186/s12868-017-0369-9
– volume: 12
  start-page: 556
  issue: 5
  year: 2016
  end-page: 576
  ident: CR13
  article-title: Small is smarter: Nano MRI contrast agents - Advantages and recent achievements
  publication-title: Small.
  doi: 10.1002/smll.201502309
– volume: 26
  start-page: 2694
  issue: 17
  year: 2014
  end-page: 2016
  ident: CR19
  article-title: Anchoring group effects of surface ligands on magnetic properties of Fe O nanoparticles: Towards high performance MRI contrast agents
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201304744
– volume: 24
  start-page: 65S
  issue: 1 Suppl
  year: 2011
  end-page: 71S
  ident: CR14
  article-title: Immunotoxicity of nanoparticles
  publication-title: Int. J. ImmunopatholPharmacol.
– volume: 13
  start-page: 95
  issue: 1
  year: 2007
  end-page: 99
  ident: CR2
  article-title: Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
  publication-title: Nat. Med.
  doi: 10.1038/nm1467
– volume: 112
  start-page: 15
  issue: 1
  year: 2006
  end-page: 25
  ident: CR29
  article-title: Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes
  publication-title: J. Control Release
  doi: 10.1016/j.jconrel.2006.01.005
– volume: 398
  start-page: 651
  issue: 2
  year: 2010
  end-page: 666
  ident: CR37
  article-title: The comet assay in nanotoxicology research
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-010-3977-0
– volume: 19
  start-page: 253
  year: 2017
  ident: CR38
  article-title: Magnetic nanoparticles: Reactive oxygen species generation and potential therapeutic applications
  publication-title: J. Nanopart. Res.
  doi: 10.1007/s11051-017-3943-2
– volume: 133
  start-page: 19512
  issue: 48
  year: 2011
  end-page: 19523
  ident: CR18
  article-title: Gelification: An effective measure for achieving differently sized biocompatible Fe O nanocrystals through a single preparation recipe
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja2081263
– volume: 8
  start-page: 2841
  year: 2012
  end-page: 2848
  ident: CR35
  article-title: Nanoparticle-induced exosomes target antigen-presenting cells to initiate Th1-type immune activation
  publication-title: Small
  doi: 10.1002/smll.201200381
– volume: 10
  start-page: 14153
  issue: 29
  year: 2018
  end-page: 14164
  ident: CR5
  article-title: PEG-copolymer-coated iron oxide nanoparticles that avoid the reticuloendothelial system and act as kidney MRI contrast agents
  publication-title: Nanoscale
  doi: 10.1039/C8NR03084G
– volume: 22
  start-page: 64
  year: 2014
  end-page: 75
  ident: CR40
  article-title: Mechanisms of nanotoxicity: Generation of reactive oxygen species
  publication-title: J. Food Drug. Anal.
  doi: 10.1016/j.jfda.2014.01.005
– volume: 26
  start-page: 57
  year: 2018
  end-page: 64
  ident: CR24
  article-title: Magnetic delivery of antitumor carboplatin by using PEGylated-Niosomes
  publication-title: DARU J. Pharma. Sci.
  doi: 10.1007/s40199-018-0215-3
– volume: 14
  start-page: 572
  issue: 5
  year: 2014
  end-page: 594
  ident: CR3
  article-title: Magnetic hyperthermia with magnetic nanoparticles: A status review
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/1568026614666140118203550
– volume: 14
  start-page: 1953
  issue: 11
  year: 2018
  end-page: 1964
  ident: CR20
  article-title: Single-dosed genotoxicity study of gold nanorod core/silver shell nanostructures by Pig-a, micronucleus, and comet assays
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2018.2640
– volume: 3
  start-page: 1
  issue: 1
  year: 2010
  end-page: 11
  ident: CR28
  article-title: Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics3010001
– volume: 11
  start-page: 986
  issue: 11
  year: 2016
  end-page: 994
  ident: CR7
  article-title: Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2016.168
– volume: 17
  start-page: 1001
  year: 2005
  end-page: 1005
  ident: CR17
  article-title: One-pot reaction to synthesize biocompatible magnetite nanoparticles
  publication-title: AdVMater
– volume: 107
  start-page: 342
  issue: 2
  year: 2009
  end-page: 351
  ident: CR10
  article-title: Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment
  publication-title: Toxicol. Sci.
  doi: 10.1093/toxsci/kfn245
– volume: 11
  start-page: 1371
  issue: 8
  year: 2023
  end-page: 1394
  ident: CR23
  article-title: Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis
  publication-title: Friction
  doi: 10.1007/s40544-022-0710-x
– volume: 41
  start-page: 203
  issue: 2
  year: 2021
  end-page: 215
  ident: CR9
  article-title: Toxicity of iron nanoparticles towards primary cultures of human bronchial epithelial cells
  publication-title: J. ApplToxicol.
– volume: 10
  start-page: 8584
  issue: 12
  year: 2010
  end-page: 8590
  ident: CR8
  article-title: Oxidative stress and apoptosis induced by iron oxide nanoparticles in cultured human umbilical endothelial cells
  publication-title: J. NanosciNanotechnol.
– volume: 14
  start-page: 977
  issue: 3
  year: 2018
  end-page: 990
  ident: CR15
  article-title: Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2018.01.014
– volume: 24
  start-page: 1358
  issue: 2
  year: 2023
  ident: CR30
  article-title: Effects of magnetic nanoparticles on the functional activity of human monocytes and dendritic cells
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms24021358
– volume: 33
  start-page: 6858
  issue: 28
  year: 2012
  end-page: 6867
  ident: CR32
  article-title: Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2012.06.016
– volume: 6
  start-page: 1074
  issue: 4
  year: 2009
  end-page: 1082
  ident: CR6
  article-title: A novel type of dual-modality molecular probe for MR and nuclear imaging of tumor: Preparation, characterization and in vivo application
  publication-title: Mol Pharm.
  doi: 10.1021/mp900143a
– volume: 19
  start-page: 327
  issue: 1
  year: 2021
  ident: CR41
  article-title: Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-021-01059-0
– volume: 452
  start-page: 580
  issue: 7187
  year: 2008
  end-page: 589
  ident: CR1
  article-title: Imaging in the era of molecular oncology
  publication-title: Nature
  doi: 10.1038/nature06917
– volume: 6
  start-page: 612
  issue: 5
  year: 2010
  end-page: 618
  ident: CR21
  article-title: Inorganic nanomedicine–part 2
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2010.04.003
– volume: 6
  start-page: 715
  issue: 4
  year: 2011
  end-page: 728
  ident: CR25
  article-title: Nanoparticle PEGylation for imaging and therapy
  publication-title: Nanomedicine
  doi: 10.2217/nnm.11.19
– volume: 143
  start-page: 138
  year: 2015
  end-page: 147
  ident: CR36
  article-title: Chronic pulmonary accumulation of iron oxide nanoparticles induced Th1-type immune response stimulating the function of antigen-presenting cells
  publication-title: Environ. Res.
  doi: 10.1016/j.envres.2015.09.030
– volume: 30
  start-page: 15
  issue: 1
  year: 2010
  end-page: 35
  ident: CR4
  article-title: Superparamagnetic iron oxide nanoparticles: Diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2009.192
– volume: 53
  start-page: 1399
  issue: 7
  year: 2012
  end-page: 1410
  ident: CR12
  article-title: Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment
  publication-title: Free RadicBiol. Med.
  doi: 10.1016/j.freeradbiomed.2012.07.011
– volume: 8
  start-page: 987
  issue: 6
  year: 2012
  end-page: 995
  ident: CR33
  article-title: Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2011.11.004
– volume: 7
  start-page: 193
  issue: 1
  year: 2011
  end-page: 194
  ident: CR31
  article-title: Impact of nanoparticles on the immune system
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2011.1264
– volume: 11
  start-page: 986
  issue: 11
  year: 2016
  ident: 48742_CR7
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2016.168
– volume: 14
  start-page: 572
  issue: 5
  year: 2014
  ident: 48742_CR3
  publication-title: Curr. Top. Med. Chem.
  doi: 10.2174/1568026614666140118203550
– volume: 11
  start-page: 1371
  issue: 8
  year: 2023
  ident: 48742_CR23
  publication-title: Friction
  doi: 10.1007/s40544-022-0710-x
– volume: 14
  start-page: 1953
  issue: 11
  year: 2018
  ident: 48742_CR20
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2018.2640
– volume: 133
  start-page: 19512
  issue: 48
  year: 2011
  ident: 48742_CR18
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja2081263
– volume: 18
  start-page: 51
  issue: 1
  year: 2017
  ident: 48742_CR39
  publication-title: BMC Neurosci.
  doi: 10.1186/s12868-017-0369-9
– volume: 26
  start-page: 57
  year: 2018
  ident: 48742_CR24
  publication-title: DARU J. Pharma. Sci.
  doi: 10.1007/s40199-018-0215-3
– volume: 19
  start-page: 253
  year: 2017
  ident: 48742_CR38
  publication-title: J. Nanopart. Res.
  doi: 10.1007/s11051-017-3943-2
– volume: 277
  year: 2022
  ident: 48742_CR22
  publication-title: Carbohydrate Polym.
  doi: 10.1016/j.carbpol.2021.118871
– volume: 17
  start-page: 1001
  year: 2005
  ident: 48742_CR17
  publication-title: AdVMater
– volume: 143
  start-page: 138
  year: 2015
  ident: 48742_CR36
  publication-title: Environ. Res.
  doi: 10.1016/j.envres.2015.09.030
– volume: 6
  start-page: 612
  issue: 5
  year: 2010
  ident: 48742_CR21
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2010.04.003
– volume: 22
  start-page: 64
  year: 2014
  ident: 48742_CR40
  publication-title: J. Food Drug. Anal.
  doi: 10.1016/j.jfda.2014.01.005
– volume: 7
  start-page: 193
  issue: 1
  year: 2011
  ident: 48742_CR31
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2011.1264
– volume: 13
  start-page: 1483
  year: 2018
  ident: 48742_CR11
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S157293
– volume: 13
  start-page: 95
  issue: 1
  year: 2007
  ident: 48742_CR2
  publication-title: Nat. Med.
  doi: 10.1038/nm1467
– volume: 8
  start-page: 987
  issue: 6
  year: 2012
  ident: 48742_CR33
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2011.11.004
– volume: 19
  start-page: 327
  issue: 1
  year: 2021
  ident: 48742_CR41
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/s12951-021-01059-0
– volume: 12
  start-page: 556
  issue: 5
  year: 2016
  ident: 48742_CR13
  publication-title: Small.
  doi: 10.1002/smll.201502309
– volume: 10
  start-page: 8584
  issue: 12
  year: 2010
  ident: 48742_CR8
  publication-title: J. NanosciNanotechnol.
– volume: 3
  start-page: 1
  issue: 1
  year: 2010
  ident: 48742_CR28
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics3010001
– volume: 33
  start-page: 6858
  issue: 28
  year: 2012
  ident: 48742_CR32
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2012.06.016
– volume: 10
  start-page: 14153
  issue: 29
  year: 2018
  ident: 48742_CR5
  publication-title: Nanoscale
  doi: 10.1039/C8NR03084G
– volume: 26
  start-page: 2694
  issue: 17
  year: 2014
  ident: 48742_CR19
  publication-title: Adv. Mater.
  doi: 10.1002/adma.201304744
– volume: 107
  start-page: 342
  issue: 2
  year: 2009
  ident: 48742_CR10
  publication-title: Toxicol. Sci.
  doi: 10.1093/toxsci/kfn245
– volume: 452
  start-page: 580
  issue: 7187
  year: 2008
  ident: 48742_CR1
  publication-title: Nature
  doi: 10.1038/nature06917
– volume: 6
  start-page: 1074
  issue: 4
  year: 2009
  ident: 48742_CR6
  publication-title: Mol Pharm.
  doi: 10.1021/mp900143a
– volume: 6
  start-page: 715
  issue: 4
  year: 2011
  ident: 48742_CR25
  publication-title: Nanomedicine
  doi: 10.2217/nnm.11.19
– volume: 8
  start-page: 2841
  year: 2012
  ident: 48742_CR35
  publication-title: Small
  doi: 10.1002/smll.201200381
– volume: 41
  start-page: 203
  issue: 2
  year: 2021
  ident: 48742_CR9
  publication-title: J. ApplToxicol.
– volume: 24
  start-page: 65S
  issue: 1 Suppl
  year: 2011
  ident: 48742_CR14
  publication-title: Int. J. ImmunopatholPharmacol.
– volume: 30
  start-page: 15
  issue: 1
  year: 2010
  ident: 48742_CR4
  publication-title: J. Cereb. Blood Flow Metab.
  doi: 10.1038/jcbfm.2009.192
– volume: 9
  start-page: 6912
  issue: 1
  year: 2019
  ident: 48742_CR16
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-43188-5
– volume: 10
  start-page: 434
  issue: 1
  year: 2015
  ident: 48742_CR34
  publication-title: Nanoscale Res. Lett.
  doi: 10.1186/s11671-015-1100-3
– volume: 11
  start-page: 126
  year: 2015
  ident: 48742_CR26
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2015.1996
– volume: 298
  start-page: 607
  issue: 2
  year: 2001
  ident: 48742_CR27
  publication-title: J. PharmacolExpTher.
– volume: 53
  start-page: 1399
  issue: 7
  year: 2012
  ident: 48742_CR12
  publication-title: Free RadicBiol. Med.
  doi: 10.1016/j.freeradbiomed.2012.07.011
– volume: 398
  start-page: 651
  issue: 2
  year: 2010
  ident: 48742_CR37
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-010-3977-0
– volume: 112
  start-page: 15
  issue: 1
  year: 2006
  ident: 48742_CR29
  publication-title: J. Control Release
  doi: 10.1016/j.jconrel.2006.01.005
– volume: 14
  start-page: 977
  issue: 3
  year: 2018
  ident: 48742_CR15
  publication-title: Nanomedicine
  doi: 10.1016/j.nano.2018.01.014
– volume: 24
  start-page: 1358
  issue: 2
  year: 2023
  ident: 48742_CR30
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms24021358
SSID ssj0000529419
Score 2.422411
Snippet Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy....
Abstract Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia...
SourceID doaj
proquest
pubmed
crossref
springer
SourceType Open Website
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 21501
SubjectTerms 631/154/1438
631/154/570
639/925/352
639/925/357
639/925/928
Animals
Diagnosis
DNA damage
Humanities and Social Sciences
Hyperthermia
Inflammation
Kidneys
Liver
Lymphocytes T
Magnetite Nanoparticles - therapeutic use
Medical diagnosis
multidisciplinary
Nanoparticles
Neoplasms
Oxidative stress
Polyethylene glycol
Polyethylene Glycols
Rats
Rats, Sprague-Dawley
Safety
Science
Science (multidisciplinary)
Toxicity
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1JS8UwEB5EELyIu3UjgjcNdknT9OgugiKo4C1kBUH6xPdE3r93kvY9d714bJqEZDKZ-cIk3wBsO2ad5spQi2cLih-CCpuXFN259godJI8UGxeX_OyWnd-Vd-9SfYU7YS09cCu4PY62VdTcaIuGNM98XVllU5vqrEDjWuhgfdHnvTtMtazeec2yunslkxZir4-eKrwmywuKGJ3l9OWDJ4qE_d-hzC8R0uh4TmZhpkOMZL8d6RxMuGYeptocksMFOLxW3g2G5I22m_Q8uTo-HT4gjLTk4vKqT1RjySP9VHjfkOsjghrQX4Tbk-ObwzPaZUagholyQLWqjGVeK1yCOryFZoblVvBA5lJ6py1j3nhtlPYshFkykRpeqFpVXmTO5MUSTDa9xq0A0bnxjpe2ElazzGjBdZaayvHKhv1sEshGUpKmow0P2SseZAxfF0K2kpUoWRklK18S2Bm3eWxJM36tfRCEP64ZCK9jAaqB7NRA_qUGCayPlk52u7AvsQUexwQrRQJb49-4f0JQRDWu9xzrIEJDoFMmsNwu-Xgk2HVZMcYS2B3pwFvnP09o9T8mtAbTIbN9vDnD12Fy8PTsNhD_DPRmVPVXi_78Tw
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT9swED8VJiReprGNLdBNnsTbZtYkjuM8IDQYDCEVIUEl3ix_TpOqFNoi6H-_s5MUbet4jGNbzn3od9blfgew55h1mitDLd4tKD4IKmxWUIRz7RUCJI8UG8MLfjZi5zfFTQ-6dketAGcrr3ahn9RoOt5_vFscosMfNCXj4usMQSgUimU5xfCbZfRhDV4gMpWho8GwDfcbru-sYmnV1s6sXvoHPkUa_1Wx5z950whHp6_gZRtHkm-N4reg5-rXsNF0lly8geMr5d18QZ7IvMnEk8uTH4sxBpeWDC8uZ0TVltzSvwZ_1eTqO0G7mL2F0enJ9fEZbfslUMNEMadalcYyrxUqpgoV0sywzAoeKF4K77RlzBuvjdKeheRLKgaG56pSpRepM1m-Dev1pHbvgejMeMcLWwqrWWq04DodmNLx0gYvNwmknZSkacnEQ0-LsYxJ7VzIRrISJSujZOVDAp-Xa24bKo1nZx8F4S9nBhrsODCZ_pStV0mOwCsqbrRFlM1SX5VW2YEd6DRH5M11Av1OdbIzLYkr8JImWCES-LR8jV4VUiWqdpP7OAfjNgx_igTeNSpfngS3LkrGWAJfOht42vz_H7Tz_Fl2YTN0so9_yvA-rM-n9-4Dxjtz_TEa8W-WJPgl
  priority: 102
  providerName: Scholars Portal
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bSx0xEB68UPClaG11vZGCb23oXrLZ7OPReuGAIpwKvoVcRZA94jki5993kr1IWyv4uNlJ2J1J9pvsZL4BOHTMOs2VoRb3FhQvBBU2LynCufYKAZJHio2LS35-zcY35c0S5H0uTDy0Hykt42e6Px32Y4ZAE5LB8oKii81y-rwMq4GqHef26mg0noyHPyshdsWyusuQSQvxSuc_UCiS9b_mYf4THY2gc7oOHztvkYza59uAJdd8gg9t_cjFJhxPlHfzBXmh7CZTT65Ozhb36EJacnF5NSOqseSB_tV415DJT4LWn32G69OTX8fntKuKQA0T5ZxqVRnLvFao_jrkQTPDcit4IHIpvdOWMW-8Nkp7FkIsmUgNL1StKi8yZ_LiC6w008ZtA9G58Y6XthJWs8xowXWWmsrxyoa1bBLIei1J01GGh8oV9zKGrgshW81K1KyMmpXPCXwb-jy0hBlvSh8F5Q-Sgew6Nkwfb2VnfMkRXkXNjbaIpXnm68oqm9pUZwXia6ET2OtNJ7sVOJPYA7digpUiga_DbVw7ISCiGjd9ijLonaGTUyaw1Zp8eBIcuqwYYwl87-fAy-D_f6Gd94nvwlqoXx_Px_A9WJk_Prl99HLm-qCb1r8BmJL0VA
  priority: 102
  providerName: Springer Nature
Title Safety evaluation of PEGylated MNPs and p-PEGylated MNPs in SD rats
URI https://link.springer.com/article/10.1038/s41598-023-48742-w
https://www.ncbi.nlm.nih.gov/pubmed/38057444
https://www.proquest.com/docview/2898758458
https://www.proquest.com/docview/2899372185
https://doaj.org/article/6212896cbd28421f97dad0d0b138013b
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swEBdby2AvY9_z1gUN9raJ-kOW5aeRZulKICEsK-RN6HMMip3VKSX__U6y4rCvvthYloV8d9L9dCfdIfTeUmMVk5oYWFsQeOCEm7wkoM6Vk6AgWQixMV-wi0s6W5fraHDr4rbK_ZwYJmrTam8jP4WFAUBrTkv-afOT-KxR3rsaU2jcR8c-dJmX6mpdDTYW78WiWR3PyqQFP-1AX_kzZXlBAKnTnNz-po9C2P5_Yc2__KRB_Zw_Ro8ibsTjntFP0D3bPEUP-kySu2dospLObnf4ELwbtw4vp192VwAmDZ4vlh2WjcEb8kfhjwavPmOQg-45ujyffptckJgfgWjKyy1RstKGOiWBEbU_EU01zQ1nPqRL6awylDrtlJbKUe9syXiqWSFrWTmeWZ0XL9BR0zb2FcIq186y0lTcKJppxZnKUl1ZVhk_qnWCsj2VhI7Bw30OiysRnNgFFz1lBVBWBMqK2wR9GL7Z9KEz7qx95ok_1PRhr0NBe_1dxFEkGChaXjOtDGjVPHN1ZaRJTaqyAjRtoRJ0smediGOxEwfJSdC74TWMIu8akY1tb0IdwGkAd8oEvexZPvQEmi4rSmmCPu5l4ND4_3_o9d19eYMe-sz1YWcMO0FH2-sb-xbwzVaNghCP0PF4PFvN4H42XSy_QumETUbBZgDXOeW_AFZX-pc
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Zb9QwEB5VRQheEDeBAkaCJ7Caw3GcB4SgB1vaXVVqK-2b8YmQqmRptlrtn-I3Ms6xK66-9TGOYznjGX8zHs8MwGvHrNNcGWrRtqD4IKiwaU4RzrVXCJC8TbExnvDRGfsyzacb8HOIhQnXKoc9sd2obW3CGfk2GgaoWguWiw-zHzRUjQre1aGERscWh265QJOteX-wi-v7Jk339053RrSvKkANE_mcalUYy7xWOP0yxBEzw1IreEiEknunLWPeeG2U9iy4KBIRG56pUhVeJM6ERAe45d9A4I2DsVdMi9WZTvCasaTsY3PiTGw3iI8hhi3NKFoGLKWL3_CvLRPwL932L79sC3f7d-FOr6eSjx1j3YMNV92Hm13lyuUD2DlR3s2XZJ0snNSeHO99Xp6j8mrJeHLcEFVZMqN_NH6vyMkuQb5rHsLZtVDuEWxWdeWeANGp8Y7nthBWs8RowXUSm8LxwoZdxESQDFSSpk9WHmpmnMvWaZ4J2VFWImVlS1m5iODt6ptZl6rjyt6fAvFXPUOa7bahvvgme6mVHIFdlNxoiyieJr4srLKxjXWSIbJnOoKtYelkL_uNXHNqBK9Wr1FqgytGVa6-bPugXojqVR7B427JVzPBofOCMRbBu4EH1oP__4eeXj2Xl3BrdDo-kkcHk8NncDsNLBlu5fAt2JxfXLrnqFvN9YuWoQl8vW4J-gXzUTPF
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxEB5VqUBcEG8WChgJTmAlu-v1OgeEaJPQUhpFlEq9uX4ipGo3NKmi_DV-HeN9Rbx663G9Xms9Hs834_HMALxyzDrNlaEWbQuKD4IKm2QU4Vx7hQDJqxQbR1O-f8I-nWanW_CzjYUJ1ypbmVgJaluacEbeR8MAVWvBMtH3zbWI2Wjyfv6DhgpSwdPaltOoWeTQrVdovi3eHYxwrV8nyWT8dW-fNhUGqGEiW1KtcmOZ1wqnMgwxxcywxAoekqJk3mnLmDdeG6U9C-6KWAwMT9VQ5V7EzoSkByj-t_NgFfVge3c8nX3pTniCD43FwyZSZ5CK_gLRMkS0JSlFO4EldPUbGlZFA_6l6f7lpa3Ab3IHbjdaK_lQs9ld2HLFPbhR17Fc34e9Y-Xdck02qcNJ6cls_HF9jqqsJUfT2YKowpI5_aPxe0GORwS5cPEATq6Fdg-hV5SFewxEJ8Y7ntlcWM1iowXX8cDkjuc2yBQTQdxSSZomdXmooHEuKxd6KmRNWYmUlRVl5SqCN9038zpxx5W9dwPxu54h6XbVUF58k80elhxhXgy50RYxPYn9MLfKDuxAxynifKoj2GmXTjaSYCE3fBvBy-417uHgmFGFKy-rPqglorKVRfCoXvLuT3DoLGeMRfC25YHN4P-f0JOr_-UF3MTdIz8fTA-fwq0kcGS4osN3oLe8uHTPUNFa6ucNRxM4u-5N9AupLzlg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Safety+evaluation+of+PEGylated+MNPs+and+p-PEGylated+MNPs+in+SD+rats&rft.jtitle=Scientific+reports&rft.au=Wen%2C+Hairuo&rft.au=Huo%2C+Guitao&rft.au=Qin%2C+Chao&rft.au=Wu%2C+Hui&rft.date=2023-12-06&rft.pub=Nature+Publishing+Group&rft.eissn=2045-2322&rft.volume=13&rft.issue=1&rft.spage=21501&rft_id=info:doi/10.1038%2Fs41598-023-48742-w&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon