Manganese-catalyzed cyclopropanation of allylic alcohols with sulfones

• Published in: Nature communications Vol. 15; no. 1; pp. 6798 - 8
• Main Authors: Yu, Ke, Nie, Qin, Chen, Qianjin, Liu, Weiping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 140/131; 140/58; 639/638/403/933; 639/638/403/934; 639/638/77/888; Agrochemicals; Alcohol; Alcohols; Alkenes; Carbenes; Cyclopropane; Dehydrogenation; Humanities and Social Sciences; Hydrogen; Manganese; multidisciplinary; Natural products; Organic compounds; Reaction mechanisms; Reagents; Science; Science (multidisciplinary); Sulfones

Cyclopropanes are among the most important structural units in natural products, pharmaceuticals, and agrochemicals. Herein, we report a manganese-catalyzed cyclopropanation of allylic alcohols with sulfones as carbene alternative precursors via a borrowing hydrogen strategy under mild conditions. V...