The Contribution of GABA to Glutamate/Glutamine Cycling and Energy Metabolism in the Rat Cortex in vivo

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 102; no. 15; pp. 5588 - 5593
• Main Authors: Patel, Anant B., de Graaf, Robin A., Mason, Graeme F., Rothman, Douglas L., Shulman, Robert G., Behar, Kevin L.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 12.04.2005; National Acad Sciences
• Subjects: Acetates; Acetates - administration & dosage; Acetates - blood; Acetates - metabolism; Acetates - pharmacology; Amino acids; Amino Acids - metabolism; Anesthesia; Anesthetics, Inhalation - pharmacology; Animals; Biological Sciences; Biological Transport - drug effects; Blood Glucose - analysis; Brain; Brain research; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Energy metabolism; Energy Metabolism - drug effects; Energy Metabolism - physiology; GABA Modulators - pharmacology; gamma-Aminobutyric Acid - biosynthesis; gamma-Aminobutyric Acid - metabolism; Glucose - administration & dosage; Glucose - pharmacology; Glutamic Acid - metabolism; Glutamine - metabolism; Halothane - pharmacology; Magnetic Resonance Spectroscopy; Male; Metabolism; Neuroglia; Neuroglia - drug effects; Neuroglia - metabolism; Neurology; Neurons; Neurons - drug effects; Neurons - metabolism; Neurotransmitters; Oxidation; Oxidation-Reduction; Pentobarbital - pharmacology; Rats; Rats, Sprague-Dawley; Rodents; Synapses

Previous studies have shown that the glutamate/glutamine (Glu/Gln) neurotransmitter cycle and neuronal glucose oxidation are proportional (1:1), with increasing neuronal activity above isoelectricity. GABA, a product of Glu metabolism, is synthesized from astroglial Gln and contributes to total Glu/...