VirB, a transcriptional activator of virulence in Shigella flexneri, uses CTP as a cofactor

• Published in: Communications biology Vol. 6; no. 1; pp. 1204 - 10
• Main Authors: Antar, Hammam, Gruber, Stephan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.11.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 14/35; 42; 42/44; 631/326/88; 631/45/147; 82/16; 82/29; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biology; Biomedical and Life Sciences; Chromosomes; Diarrhea; DNA - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Gene silencing; Gram-negative bacteria; Life Sciences; Microenvironments; Nucleotide sequence; Promoter Regions, Genetic; Shigella flexneri; Shigella flexneri - genetics; Shigellosis; Supercoiling; Transcription activation; Transcription Factors - genetics; Transcription Factors - metabolism; Virulence; Virulence - genetics; Virulence Factors - genetics

VirB is a transcriptional activator of virulence in the gram-negative bacterium Shigella flexneri encoded by the large invasion plasmid, pINV. It counteracts the transcriptional silencing by the nucleoid structuring protein, H-NS. Mutations in virB lead to loss of virulence. Studies suggested that V...