Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans

• Published in: Psychopharmacologia Vol. 197; no. 3; pp. 421 - 431
• Main Authors: Ersche, Karen D., Roiser, Jonathan P., Robbins, Trevor W., Sahakian, Barbara J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.04.2008; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Amphetamine - toxicity; Amphetamine-Related Disorders - psychology; Amphetamines; Appetitive Behavior - drug effects; Association Learning - drug effects; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Brain research; Central Nervous System Stimulants - toxicity; Choice Behavior - drug effects; Cocaine; Cocaine - toxicity; Cocaine-Related Disorders - psychology; Cognition & reasoning; Dopamine Uptake Inhibitors - toxicity; Drug use; Female; Humans; Male; Medical sciences; Middle Aged; Motivation; Neuropharmacology; Neurosciences; Opioid-Related Disorders - psychology; Original Investigation; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Probability Learning; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Receptors, Serotonin - drug effects; Reversal Learning - drug effects; Reward; Stereotyped Behavior - drug effects; Amphetamines; Opiates; Perseveration; Cocaine; Probabilistic reversal learning; Serotonin; Amphetamine derivatives; Human; CNS stimulant; Psychotropic; Ester; Chronic; Probabilistic reversal learning, Serotonin; Reversal learning; Neurotransmitter; Amfetamine; Probability learning; Drug of abuse

Rationale Chronic drug use has been associated with increased impulsivity and maladaptive behaviour, but the underlying mechanisms of this impairment remain unclear. We investigated the ability to adapt behaviour according to changes in reward contingencies, using a probabilistic reversal-learning t...