Anti-inflammatory function of ginsenoside Rg1 on alcoholic hepatitis through glucocorticoid receptor related nuclear factor-kappa B pathway

• Published in: Journal of ethnopharmacology Vol. 173; no. NA; pp. 231 - 240
• Main Authors: Gao, Yan, Chu, Shifeng, Li, Jingwei, Li, Jianping, Zhang, Zhao, Xia, Congyuan, Heng, Yang, Zhang, Meijin, Hu, Jinfeng, Wei, Guining, Li, Yueting, Chen, Naihong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 15.09.2015
• Subjects: Alanine Transaminase - blood; alcohol drinking; Alcoholic hepatitis; alcohols; animal models; Animals; Anti-inflammation; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Aspartate Aminotransferases - blood; binging; blood serum; China; Cholesterol - blood; cytokines; Cytokines - metabolism; dexamethasone; Ginsenoside Rg1; ginsenosides; Ginsenosides - pharmacology; Ginsenosides - therapeutic use; Glucocorticoid receptor; glucocorticoid receptors; Hepatitis, Alcoholic - blood; Hepatitis, Alcoholic - drug therapy; Hepatitis, Alcoholic - metabolism; Hepatitis, Alcoholic - pathology; immunohistochemistry; ingredients; Japan; Korean Peninsula; L-Lactate Dehydrogenase - blood; liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; mice; Mice, Inbred C57BL; microscopy; mortality; NF-kappa B - antagonists & inhibitors; NF-kappa B - metabolism; NF-κB pathway; Panax; Panax ginseng; Plant Roots; Protective Agents - pharmacology; Protective Agents - therapeutic use; Receptors, Glucocorticoid - metabolism; traditional medicine; transcription factor NF-kappa B; Triglycerides - blood; triterpenoid saponins; Western blotting; China; Japan; Korean Peninsula; Ginsenoside Rg1; Alcoholic hepatitis; Anti-inflammation; Glucocorticoid receptor; NF-κB pathway

Ginseng is the dried root of Panax ginseng C.A. Mayer. Since ancient times, ginseng has been used as one kind of treatment drug or tonic in China and even other eastern countries like Korea and Japan. Pharmacological active chemical ingredients and its extract of ginseng are a mixture of triterpenoi...