Biological Role and Potential Therapeutic Targeting of the Chemokine Receptor CXCR4 in Undifferentiated Thyroid Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 67; no. 24; pp. 11821 - 11829
• Main Authors: DE FALCO, Valentina, GUARINO, Valentina, AVILLA, Elvira, DOMENICA CASTELLONE, Maria, SALERNO, Paolo, SALVATORE, Giuliana, FAVIANA, Pinuccia, BASOLO, Fulvio, SANTORO, Massimo, MARINA MELILLO, Rosa
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.12.2007
• Subjects: Antineoplastic agents; Biological and medical sciences; Carcinoma - pathology; Cell Division; Cell Line, Tumor; Cells, Cultured; Endocrinopathies; Flow Cytometry; Humans; Immunohistochemistry; Malignant tumors; Medical sciences; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Pharmacology. Drug treatments; Polymerase Chain Reaction; Receptors, CXCR4 - drug effects; Receptors, CXCR4 - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger - genetics; RNA, Neoplasm - genetics; Thyroid Gland - physiology; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology; Thyroid. Thyroid axis (diseases); Tumors; Endocrinopathy; Thyroid cancer; Targeted therapy; Thyroid diseases; Malignant tumor; CXCR4 chemokine receptor; Cancer

Anaplastic thyroid carcinoma (ATC) is a rare thyroid cancer type with an extremely poor prognosis. Despite appropriate treatment, which includes surgery, radiotherapy, and chemotherapy, this cancer is invariably fatal. CXCR4 is the receptor for the stromal cell-derived factor-1 (SDF-1)/CXCL12 chemok...