Obesity in autoimmune diseases: Not a passive bystander

• Published in: Autoimmunity reviews Vol. 13; no. 9; pp. 981 - 1000
• Main Authors: Versini, Mathilde, Jeandel, Pierre-Yves, Rosenthal, Eric, Shoenfeld, Yehuda
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2014
• Subjects: Adipokines; Allergy and Immunology; Animals; Autoimmune diseases; Autoimmune Diseases - complications; Autoimmune Diseases - immunology; Autoimmunity; Humans; Inflammation - immunology; Obesity; Obesity - complications; Obesity - immunology; Overweight; Risk Factors; Thyroid Gland - immunology; White adipose tissue; CRP; RR; Autoimmunity; TNFα; Anti-Tg; T1D; iNK cells; HR; IBD; WAT; HT; ACPA; SLE; UC; Overweight; CSF; BMI; Th17 cells; IFNγ; Anti-TPO; CD; Obesity; PASI; IL; OR; White adipose tissue; AIM; ESR; MS; T2D; EAE; TSH; Adipokines; CCL; PBMC; RA; ACR; HAQ; NLRP3-inflammasome; Treg cells; Foxp3; HLA; Autoimmune diseases; TAI; PsA; C-reactive protein; anti-thyroglobulin antibodies; invariant natural killer T cells; odds ratio; Psoriasis Area and Severity Index; Health Assessment Questionnaire; cerebro-spinal fluid; experimental autoimmune encephalomyelitis; Forkhead box protein 3; ulcerative colitis; interferon gamma; human leukocyte antigen; body mass index; thyroid autoimmunity; chemokine ligand; rheumatoid arthritis; inflammatory bowel disease; relative risk; Anti-citrullinated protein antibodies; psoriatic arthritis; white adipose tissue; apoptosis inhibitor of macrophage; NOD-like receptor protein 3-inflammasome; systemic lupus erythematosus; tumor necrosis factor alpha; American College of Rheumatology; interleukin; T-helper 17 cells; erythrocyte sedimentation rate; T-regulatory cells; type-2 diabetes; multiple sclerosis; Crohn's disease; thyroid-stimulating hormone; Hashimoto thyroiditis; hazard ratio; anti-thyroperoxydase antibodies; type-1 diabetes; peripheral blood mononuclear cell

In the last decades, autoimmune diseases have experienced a dramatic increase in Western countries. The involvement of environmental factors is strongly suspected to explain this rise. Particularly, over the same period, obesity has followed the same outbreak. Since the exciting discovery of the sec...