Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma

• Published in: Nature communications Vol. 15; no. 1; pp. 1009 - 18
• Main Authors: Liu, Chunxiao, Zhou, Chenhao, Xia, Weiya, Zhou, Yifan, Qiu, Yufan, Weng, Jialei, Zhou, Qiang, Chen, Wanyong, Wang, Ying-Nai, Lee, Heng-Huan, Wang, Shao-Chun, Kuang, Ming, Yu, Dihua, Ren, Ning, Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/109; 13/31; 13/51; 13/95; 631/67/1059; 631/67/580; 692/4028/67/1504/1610/4029; Antibodies; Cancer; Cancer immunotherapy; CD8 antigen; Cytotoxicity; Hepatocellular carcinoma; Humanities and Social Sciences; Immune checkpoint inhibitors; Immunity; Immunosuppression; Immunotherapy; Kinases; Liver cancer; Lymphocytes T; Lymphoma; Macrophages; Microenvironments; Monoclonal antibodies; multidisciplinary; PD-1 protein; Phenotypes; Polarization; Protein-tyrosine kinase; Proteins; Ribonuclease; Science; Science (multidisciplinary); Signal transduction; Tumor microenvironment; Tumors

Tumor-secreted factors contribute to the development of a microenvironment that facilitates the escape of cancer cells from immunotherapy. In this study, we conduct a retrospective comparison of the proteins secreted by hepatocellular carcinoma (HCC) cells in responders and non-responders among a co...