The role of vitamin E in atherogenesis: linking the chemical, biological and clinical aspects of the disease

• Published in: Atherosclerosis Vol. 157; no. 2; pp. 257 - 283
• Main Authors: Neuzil, Jiri, Weber, Christian, Kontush, Anatol
• Format: Book Review Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.08.2001; Elsevier
• Subjects: Animals; Arteriosclerosis - etiology; Atherogenesis; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Disease Progression; Epidemiology; Humans; Immune system; Immune System - physiology; LDL modification; Medical sciences; Oxidation; Oxidation-Reduction; Signal Transduction - physiology; Signalling; Supplementation; Vascular biology; Vitamin E; Vitamin E - physiology; Atherogenesis; TNFα, tumour necrosis factor-α; ICAM1, intercellular adhesion molecule-1; Epidemiology; MI, myocardial infarction; Vitamin E; TMP, tocopherol-mediated peroxidation; apoE, apolipoprotein E; oxLDL, oxidised LDL; Oxidation; IU, international unit(s); VCAM1, vascular cell adhesion molecule-1; Supplementation; LDL, low-density lipoprotein; LO, (15-)lipoxygenase; Immune system; NFκB, nuclear factor κB; SMC, smooth muscle cell(s); PKC, protein kinase C; LDL modification; MC, monocytic cell(s); Signalling; α-TOH, α-tocopherol; Vascular biology; PLA 2, phospholipase A 2; WHHL, Watanabe heritable hyperlipidemic (rabbit); O 2 − , superoxide (anion); EC, endothelial cell(s); IL, interleukin; PPARγ, peroxisome proliferator-activated receptor-γ; α-TOS, α-tocopheryl succinate; MCP1, monocyte chemoattractant protein-1; Vascular disease; Human; Lipoprotein LDL; Pathophysiology; Atherosclerosis; Cardiovascular disease; Exploration; Review; E-Vitamins

Athersclerosis is a disease involving both oxidative modifications and disbalance of the immune system. Vitamin E, an endogenous redox-active component of circulating lipoproteins and (sub)cellular membranes whose levels can be manupulated by supplementation, has been shown to play a role in the ini...