Profile of drug resistance mutations among HIV-1-infected Tunisian subjects failing antiretroviral therapy

• Published in: Archives of virology Vol. 153; no. 6; pp. 1103 - 1108
• Main Authors: Jlizi, A, Ben Ammar El Gaaied, A, Slim, A, Tebourski, F, Ben Mamou, M, Ben Chaabane, T, Letaief-Omezzine, A, Chakroun, M, Garbouj, M, Ben Rejeb, S
• Format: Journal Article
• Language: English
• Published: Vienna Vienna : Springer Vienna 01.06.2008; Springer Vienna; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Anti-HIV Agents; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Antiretroviral Therapy, Highly Active; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; codons; drug effects; Drug resistance; Drug Resistance, Viral; Drug Resistance, Viral - genetics; Drug therapy; epidemiology; Female; Fundamental and applied biological sciences. Psychology; genetics; HIV; HIV Infections; HIV Infections - drug therapy; HIV Infections - prevention & control; HIV Infections - virology; HIV Protease; HIV Protease - genetics; HIV Protease Inhibitors; HIV Protease Inhibitors - pharmacology; HIV Protease Inhibitors - therapeutic use; HIV Reverse Transcriptase; HIV Reverse Transcriptase - genetics; HIV-1; HIV-1 - drug effects; HIV-1 - genetics; Human immunodeficiency virus; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunology; Infections; Infectious Diseases; Male; Medical Microbiology; Medical sciences; Microbiology; Miscellaneous; Mutation; Original Article; patients; pharmacology; Plasma; Polymerase chain reaction; prevention & control; proteinase inhibitors; Retrospective Studies; Reverse Transcriptase Inhibitors; Reverse Transcriptase Inhibitors - pharmacology; Reverse Transcriptase Inhibitors - therapeutic use; RNA-directed DNA polymerase; therapeutic use; therapeutics; Treatment Failure; Tunisia; Tunisia - epidemiology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virology; Tunisia; North Africa; United States > US; Germany; Resistance Mutation; Human Immunodeficiency Virus Infection; Protease Gene; Human Immunodeficiency Virus; Drug Resistance Mutation; Infection; Resistance; Immunopathology; Chemotherapy; Treatment; Viral disease; Antiviral; AIDS; Mutation; Immune deficiency

Three years after the introduction of antiretroviral therapy (ART) in Tunisia (North Africa), we aimed to determine the prevalence of drug resistance mutations in Tunisian HIV-1-infected patients failing ART. Plasma samples of 80 patients were tested for genotypic resistance using two distinct line...