Epidermal Growth Factor Receptor Regulates Normal Urothelial Regeneration

• Published in: Laboratory investigation Vol. 83; no. 9; pp. 1333 - 1341
• Main Authors: Daher, Ahmad, de Boer, Willem I, El-Marjou, Ahmed, van der Kwast, Theodorus, Abbou, Claude C, Thiery, Jean-Paul, Radvanyi, François, Chopin, Dominique K
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.09.2003; Nature Publishing Group US; Nature Publishing; Nature Publishing Group
• Subjects: Amphiregulin; Antibodies, Blocking - pharmacology; Biological and medical sciences; Blotting, Western; Bromodeoxyuridine - metabolism; Cell Division - drug effects; Cell Movement - drug effects; Cells, Cultured; DNA Primers - chemistry; EGF Family of Proteins; Epidermal Growth Factor - pharmacology; ErbB Receptors - genetics; ErbB Receptors - immunology; ErbB Receptors - metabolism; Glycoproteins - pharmacology; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins - pharmacology; Laboratory Medicine; Medical sciences; Medicine; Medicine & Public Health; Nephrology. Urinary tract diseases; Pathology; Quinazolines; Regeneration - drug effects; Regeneration - physiology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Time Factors; Transforming Growth Factor alpha - pharmacology; Tyrphostins - pharmacology; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland; Urothelium - drug effects; Urothelium - metabolism; Urothelium - pathology; Wound Healing - drug effects; Wound Healing - physiology; Cell proliferation; Human origin; Cell culture; Regeneration; Signal transduction; Urinary system disease; Epidermal growth factor; Lesion; Urinary tract; Epithelium; Biological receptor

Members of the epidermal growth factor (EGF) family and their receptors are involved in many cellular processes, including proliferation, migration, and differentiation. We have previously reported that these growth factors are expressed and have specific regulatory functions in an organ-like cultur...